Box―Behnken设―效应面法优选蒲黄干法制粒工艺.docVIP

Box―Behnken设计―效应面法优选蒲黄干法制粒工艺 　　摘要：目的 优选蒲黄干法制粒工艺。方法 以颗粒得率和脆碎度为评价指标，以药粉含水量、压片变频、制粒变频为考察因素，采用单因素试验考察各因素对指标的影响程度，采用Box-Behnken设计考察各因素对评价指标总评OD值的影响，并采用效应面法预测、分析、优化最佳工艺。结果 最佳干法制粒工艺为药粉含水量35.0%，压片变频27 Hz，制粒变频15 Hz。结论 所选工艺稳定、可行、重现性好，可用于蒲黄的制粒。 中国论文网 /1/viewhtm　　关键词：蒲黄；Box-Behnken设计-效应面法；干法制粒 　　DOI：10.3969/j.issn.1005-5304.2018.01.018 　　中图分类号：R283.5 文献标识码：A 文章编号：1005-5304（2018）01-0084-05 　　Optimization of Dry Granulation Technology of Typha Pollen Granules 　　by Box-Behnken Design and Response Surface Method 　　FAN Ling-yun， YU Yan， GAO Jian-de， JIN Hui 　　Gansu University of Chinese Medicine， Key Laboratory of Chemistry and Quality for Traditional Chinese and Tibetan Medicines of the University of Gansu Province， Lanzhou 730000， China 　　Abstract： Objective To optimize the dry granules process of Typha Pollen. Methods The particle size and particle friability were selected as evaluation indexes. The inspect factors were water content， compression frequency， and granulation frequency. Influence of inspect factors on evaluation indexes was investigated by single factor test， the influence of inspect factors on OD value was investigated by Box-Behnken design， and response surface method was adopted to predict， analyze and choose optimal process. Results The optimal dry granulation technology was as follows： the water content was 35.0%； the frequency of tabletting was 27 Hz； the granulating frequency was 15 Hz. Conclusion The selected process is stable， feasible and reproducible， which can be used for granulation of Typha Pollen granules. 　　Keywords： Typhae Pollen； Box-Behnken design-response surface method； dry granulation 　　蒲黄为香蒲科植物水烛香蒲Typha angustifolia L.、东方香蒲Typha orientalis Presl或同属植物的干燥花粉[1]，其味甘、性平，归肝、心包经，具有止血、化瘀、通淋之功效，主治吐血、衄血、咯血、崩漏、外伤出血、经闭痛经、胸腹刺痛、血淋涩痛等症[2]。蒲黄作为可用于保健品开发的中药材，应用日益广泛。但蒲黄为花粉类药物，分散度高，流动性差，易吸湿，携带和服用不便。采用干法制粒工艺，将蒲黄药材原粉直接制成颗粒状产品，较传统湿法制粒工艺更为简便易行，且所得蒲黄颗粒流动性好，不易吸湿，性质更稳定，方便保存，又可作为片剂、胶囊剂等剂型的中间体直接应用。本研究采用Box-Behnken设计-效应面法优化蒲黄干法制粒工艺，为蒲黄药材原粉的开发 　　基金项目：甘肃省自然科学基金（15