氨溴索联合阿奇霉素治疗儿童支原体肺炎临床效果观察与分析.docVIP

氨溴索联合阿奇霉素治疗儿童支原体肺炎临床效果观察与分析 　　[摘要] 目的 探讨氨溴索联合阿奇霉素治疗儿童支原体肺炎的临床效果，并分析其对肺功能的影响。 方法 随机选择宁波市第六医院2013年1月～2014年4月收治的196例儿童支原体肺炎患者，根据治疗方法将所有患儿分为干预组和对照组，对照组患儿95例，在常规治疗基础上应用阿奇霉素治疗；干预组101例，应用氨溴索联合阿奇霉素治疗。观察1个疗程后的治疗效果和肺功能指标如用力肺活量（FVC）、第1秒最大呼气量（FEV1）、最高呼气流速（PEF）、用力呼气25%流速（MEF25）、用力呼气50%流速（MEF50）的变化；并观察治疗期间患儿主要症状或体征消失时间以及不良反应等结果。 结果 干预组患儿总有效率为96.05%（96/101），高于对照组[86.32%（82/95）]，差异有统计学意义（P 0.05）。 结论 氨溴索联合阿奇霉素治疗儿童支原体肺炎临床效果较好，能够显著改善患儿肺功能，缩短患儿治疗时间。 　　[关键词] 支原体肺炎；儿童；阿奇霉素；氨溴索 　　[中图分类号] R563.1 [文献标识码] A [文章编号] 1673-7210（2014）10（a）-0062-04 　　Observation and analysis of the clinical effect of Ambroxol combined with azithromycin in the treatment of the children with mycoplasma pneumonia 　　ZHU Guozhu 　　Department of Pediatrics， the Sixth Hospital of Ningbo City， Zhejiang Province， Ningbo 315040， China 　　[Abstract] Objective To explore the clinical effect of Ambroxol combined with azithromycin in the treatment of the children with mycoplasma pneumonia， and to analyze its effect on lung function. Methods 196 children patients with mycoplasma pneumonia from January 2013 to April 2014 in the Sixth Hospital of Ningbo City were randomly selected， they were divided into intervention group and control group according to the treatment methods. 95 patients of the control group， were treated with azithromycin on the basis of conventional therapy， 101 patients in the intervention group， were treated with Ambroxol combined with azithromycin. the therapeutic effect and lung function changes after a treatment course， the forced vital capacity （FVC）， forced expiratory volume in one second （FEV1）， peak expiratory flow rate （PEF）， forced expiratory flow rate of 25% （MEF25）， forced expiratory flow rate of 50% （MEF50） were observed， and the main symptoms and signs disappeared time and adverse reaction results during the treatment period were observed. Results The total effective rate of the intervention group was 96.05% （96/101）， more than that of control group [86.32% （82/95）]， there was significant differen