帕利哌酮缓释片用于精神分裂症复发研究进展.docVIP

帕利哌酮缓释片用于精神分裂症复发研究进展 　　[摘要] 帕利哌酮缓释片是目前临床常用的一种非典型抗精神病药物，临床作用机制是主要通过阻断全部的5-羟色胺2A（5-HT2A）受体和部分多巴胺D2（DA2）受体，进而发挥抗精神病的作用。近年来，随着帕利哌酮缓释片在临床上被广泛应用，许多临床研究提示帕利哌酮缓释片可有效控制精神分裂症患者的阳性症状、改善阴性症状和认知损害、提高患者的耐受性和依从性。帕利哌酮缓释片起效快，且可有效改善对其他非典型抗精神病药治疗无效患者的临床效果，为精神分裂症患者的全面康复提供有效的治疗。近年来的统计观察发现，帕利哌酮缓释片应用于急性期及首发精神分裂症患者的临床效果较好，临床治愈率满意，但帕利哌酮缓释片对精神分裂症复发的效果如何尚未报道。本院通过对住院或门诊复发精神分裂症患者应用帕利哌酮缓释片的观察，评价帕利哌酮缓释片治疗精神分裂症复发的临床效果。本研究对帕利哌酮缓释片治疗精神分裂症复发的研究进行综述。 　　[关键词] 帕利哌酮缓释片；精神分裂症；复发；研究进展 　　[中图分类号] R749.3 [文献标识码] A [文章编号] 1674-4721（2014）09（b）-0191-03 　　Research progress of paliperidone extended-release tablet applied in schizophrenia relapse 　　HUANG Yu 　　Department of Pharmacy，Brains Hospital of Hunan Province，Changsha 410007，China 　　[Abstract] Paliperidone extended-release tablet is used as a common atypical antipsychotic drugs，and its clinical mechanism of action is mainly blocking all 5-HT2A receptor and partial DA2 receptor in order to play the role of anti psychotic.In recent years，with the extensive use of paliperidone extended-release tablet in the clinic，many study showed that paliperidone extended-release tablet can effectively control the positive symptoms of patients with schizophrenia，improve negative symptoms and cognitive impairment and improve the tolerance and compliance patients.Paliperidone extended-release tablet with rapid action can effectively improve the clinical efficacy of other patients treated inefficiently by other atypical antipsychotics therapy，and it can provide effective treatment for the comprehensive rehabilitation of patients with schizophrenia.Some statistics in recent years showed that paliperidone extended-release tablet used in the acute schizophrenia was effective，with a satisfaction of clinical cure rate，but the study about paliperidone extended-release tablet used in the schizophrenia recurrence had not been reported.Our hospital evaluates clinical curative effect of paliperidone extended-release tablet for the treatment of schizophrenia recurrence by observation of s