全自动dna图像研究仪及多指标检测在胸腔积液诊断中的应用价值-application value of full-automatic dna image research instrument and multi-index detection in diagnosis of pleural effusion.docxVIP

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全自动dna图像研究仪及多指标检测在胸腔积液诊断中的应用价值-application value of full-automatic dna image research instrument and multi-index detection in diagnosis of pleural effusion.docx

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全自动dna图像研究仪及多指标检测在胸腔积液诊断中的应用价值-application value of full-automatic dna image research instrument and multi-index detection in diagnosis of pleural effusion

华中科技大学硕士学位论文华中科技大学硕士学位论文 5 5 got a sensitivity of 94.12% and a specificity of 87.8%, positive predictive value of 76.19%, negative predictive value of 97.3%, correct rate of 89.66% with the the Automatic DNA image analysis system. The sensitivity and specificity of the routine cytologic diagnosis were 82.35% and 92.15%. If we connect the Automatic DNA image analysis system and the routine cytologic diagnosis, we can get a sensitivity and specificity of 100% and 82.93%. The level of serum CEA in the malignant group (33.24mmol/L) is much higher than in the benign group (1.39mmpl/L), there is significant statistics difference between them (P0.000). The level of CEA in pleural effusion in the malignant group (270.44mmol/L) is much higher than in the benign group (0.94mmol/L), P0.000, the statistics difference was obvious. The value of pleural effusion CEA/serum CEA was higher in malignant group (13.30) than in the benign group (0.89), there is significant statistic difference between the two groups. If we set the level of CEA in bood at the point of 4.045mmlol/l we can get a specialty of 100%. We did not find any correlation between the number of aneuploidy and the level of CEA in either serum or pleural effusions in our study, and smoking does not correlate with malignant pleural effusions. Conclusion: The Automatic DNA Image Cytometry is of very important value in the diagnosis and the differential diagnosis of benigh and the malignant pleural fluids; the level of CEA in both serum and pleural fluids and the value of pleural fluid CEA/serum CEA are all well markers of the diagnosis of malignant pleural effusions; Combined with the routine cytology and other clinical examination facility, we can deeply distinct the cause of disease and improve the accuracy and the sensitivity of the diagnosis. Keyword: Automatic DNA Image Cytometry；fluid based lamellar smear；CEA；LDH， DNA ploidy 1 1 缩略词表 DNA-ICM：Automatic DNA Image Cytometry 全自动 DNA 图像分析仪 Feulgen-Thionin sta