杀伤细胞免疫球蛋白样受体基因及其与血脂交互作用对高血压影响-effect of killer cell immunoglobulin-like receptor gene and its interaction with blood lipid on hypertension.docxVIP

杀伤细胞免 杀伤细胞免疫球蛋白样受体基因及其与血脂的交互作用对高血压的影响 英文摘要 PAGE PAGE III IV IV Effects of killer cell immunoglobulin-like receptor gene and their interaction with blood lipids on hypertension Abstract Background Few study reported the effects of killer cell immunoglobulin-like receptor(KIR) genes and their interaction with blood lipids on hypertension. Purpose To explore the association between each of KIR genes, KIR genotypes, interaction among KIR genes, interaction among KIR genes with blood lipids and hypertension, providing basis for genetic mechanism and prevention and control of hypertension Methods A cross-sectional study was conducted between Mar. 1, 2010 to April 30, 2010 in 3061 subjects aged 30 years and older in four communities in Jinchang District of Suzhou, China. Trained and qualified investigators collected data on the information of demographic characteristics, lifestyle and medical history. Meanwhile, blood samples were collected for all the subjects, and blood lipids and fasting blood glucose were tested. On the basis of above investigation, we extracted DNA from blood samples for all the subjects. 205 hypertensives and 205 healthy individuals were selected as cases and controls to conduct a 1:1 matched case-control study, the genetic polymorphisms of KIR genes were examined for all cases and controls. Statistic analysis was conducted by using SAS 9.1 and GMDR software. The univariate and multivariable conditional logistic regression was used to analyze the association between each of KIR genes and hypertension. GMDR and conditional logistic regression were used to analyze the association between interaction of KIR genes and hypertension. GMDR was used to analyze the interaction of KIR genes with blood lipids on hypertension. Results There were no significant difference in every KIR genes between hypertensive 英文摘要 杀伤细胞免疫球蛋白样受体基因及其与血脂的交互作用对高血压的影响 subjects and normotensive subjects(P0.05). In conditional logistic regression model, none of the 16 KIR genes