微束物理性能的研究和微束装置的设计研究-study on the physical properties of microbeam and design of microbeam device.docx

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微束物理性能的研究和微束装置的设计研究-study on the physical properties of microbeam and design of microbeam device.docx

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微束物理性能的研究和微束装置的设计研究-study on the physical properties of microbeam and design of microbeam device

MicrobeamPropertyStudi创andMicrobeamEquipmelltDesignAbstractShixiangPeng(nuclear四町gysClence阻dengineering)DirectedbyProfs.Zengli四gYuandShaohuWangThecharged-particlemicrobeamhasbeendesignedtoenablece!lsinvitrotobeirradiatedindividual\ywithmicronprecisi阻，andw恤precisenumbersofoh町gedp缸tic1esdeliveredtopredeterminedlocationsineachcel1nucleusoroyto抖部m.Therationaleforthisapproachis也atitispossibletodeviseexperimentsthat缸.eamorerealisticrepresentationofthesituationrelevanttoenvironmental四do∞upationalexposurestocharged-particles.Inrecentyears，severalcharged.二particlemicrobeamfaαlitieshavebeendevelopedintheworldInmicrobe田nexpenme泪t，cellsonadishareindividuallyirradiatedbyapredefinedexactnumberofalphaparticles，allowing也π巳ctsofexactlyone(ormore)alphaparticie阳versalsto盯.adiatesignificantnumbersofcel1s.Uptonow，thereare队NOmicrobeamlaboratorieswhicharebeingusedtoirradiatecellsevetγday，oneissituatedattheGrayLaboratoryCancerResearchTru町，theotherislocatedintheCenterforRadiologicalResearch(CRR)atColumbiaUniversityForthemicrobeammachine，themaintarge吨ofitistocontrolthenumherofpartic1臼toaspecifictargetwithinanindividualcellwithahighdegreeofaccurac予Unfortunately，threeisnor叩orton世lìsuntil飞hisresearchstarts.lnordertoinvestigatetheoveraHta皂etingandaiffiing部curacyofthemicroheamsystem，aseriesofexperimentshavebeencompletedontheGrayLabmicrobeam.Theresearchisnotonlygiveusthespatialresolution阻dthedetectorefficiencyoftheGrayLabmicrobeamandshowusthecoursescausingthecharged-particlesscatter，butalsoletusknowthefust-handdatafor0出gn创1ourmicrobeamfacility.AIIthedataarefirstfoundintheworldFm也e孔t[jcrobeam:fi泣ilityintheInstituteofPlasm王Physics，thedesireP胆netersisasfollowìng由espatialre回lutìonisless也皿2μm，thedetectOfefficiencyisbetterthan99肘，血d由espeedofcellirradiationìs3000-5000/hrslnordertodevelop0町ownmicrobeam，asystemusesacombinationof四mputerizedimagingandimageprocessing，amicropositioningmicroscope咆eandmicrocollimationofaradiationbeamfromaVandeGr田ffacceleratorhasbeendesignedinthis也esis.TheHPLCorCompoundlas町holeco