心肌梗死后左室功能变化及心室重塑的磁共振成像分析-magnetic resonance imaging analysis of left ventricular function changes and ventricular remodeling after myocardial infarction.docxVIP

华中科技大学博士学位论文 华 中 科 技 大 学 博 士 学 位 论 文 PAGE 10 PAGE 10 Evaluation of Left Ventricular Function and Remodeling after Myocardial Infarction by Magnetic Resonance Imaging ABSTRACT Part 1 MRI evaluation of postoperative pericardial adhesions in rabbit models of myocardial infarction Objective: The aim of the present study was to investigate the role of MRI in evaluating postoperative pericardial adhesions in rabbit models of myocardial infarction. Methods: Twenty-five Japanese white rabbits were randomly divided into conventional operation group (n=11) and anti-adhesion membrane placed group (n=14), both underwent chest-opening coronary artery ligation surgery. After 8 weeks, in vivo MRI and exploratory thoracotomy were performed respectively to observe the degree of adhesions according to respective criteria. Data were analyzed by Wilcoxons rank test. The consistence between MRI and exploratory thoracotomy were detected using consistency check. Results: The number of none adhesion, mild adhesions and severe adhesions observed by MRI were 3, 3, 5 cases respectively in conventional operation group and 4, 9, 1 cases respectively in anti-adhesion membrane placed group; the number observed by exploratory thoracotomy were 2, 4, 5 cases in conventional operation group and 5, 7, 2 cases in anti-adhesion membrane placed group. The difference between the two groups was statistically significant. (P=0.021 from MRI, and P=0.025 from reoperation). The cases of none adhesions, mild adhesions and severe adhesions from MRI consistent with exploratory thoracotomy were 5, 9, 6 cases. MRI results were consistent with exploratory thoracotomy results (Kappa =0.69, p0.001). Conclusions ：Magnetic resonance imaging assessment of pericardial adhesions is in good agreement with exploratory thoracotomy, MRI would be a good means of adhesions evaluation after cardiac surgery. Key words ：Myocardial infarction, Animal model, Tissue adhesions, Magnetic resonance imaging Part 2 Effect of postopera