33例鼻咽癌复发相关因素分析.docVIP

33例鼻咽癌复发相关因素分析 　　【摘要】 目的：探讨鼻咽癌复发的相关临床和治疗因素。方法：收集江门市中心医院2006-2010年有病理确诊的鼻咽癌首次治疗后鼻咽复发患者33例，所有患者首次治疗均接收过根治性放疗，对复发的时间间隔、T及N分期、是否化疗等进行统计学分析。结果：中位复发时间26个月，复发的患者中，T3～4的患者有22例，占66.67%，而N2～3的患者仅12例，占36.67%，两者比较差异有统计学意义（P=0.026）。初次治疗有14例患者接受过化疗联合放疗为化疗组，有19例患者未接受化疗为非化疗组，接受化疗的患者复发的中位时间为（35.90±14.55）个月，未接受化疗的患者的复发中位时间为（28.47±18.85）个月，两组比较差异无统计学意义（P=0.227）。结论：鼻咽癌的复发在治疗后3年内发生几率高，相关因素可能与T分期以及有无化疗有关，对于局部T晚期的鼻咽癌的患者，初次治疗时放疗适当加化疗或许有益。 　　【关键词】 鼻咽癌； 复发； 化学疗法； 临床因素 　　Related Factors Analysis of 33 Patients with Recurrent Nasopharyngeal Carcinoma/WANG Yu，CHEN Guo-jian，DENG Li-nong，et al.//Medical Innovation of China，2015，12（20）：034-037 　　【Abstract】 Objective：To explore the clinical and therapeutic factors related to local recurrent nasopharyngeal carcinoma（rNPC）. Method：The clinical data of 33 patients diagnosed with local rNPC for the first time on the base of pathology and or imaging in our hospital were collected from 2006 to 2010， all patients received radical radiotherapy for the first time， such factors as sex，age，clinical stage and chemotherapy were analysed and compared. Result：Median interval of relapse was 26 months.Patients of stages T3-4 in 92’Fuzhou staging system were 22 cases， accounted for 66.67%，while stages N2-3 were 12 cases， accounted for 36.67%， the difference was statistically significant （P=0.026）.14 patients received chemotherapy and radiotherapy in the first time treatment as the chemotherapy group，19 patients received only radiotherapy as the no chemotherapy group. Median interval relapse of two groups were respectively （35.90±14.55）months and （28.47±18.85）months，there was no statistically significant difference （P=0.227）.Conclusion：The most common interval of local relapse is about 3 years，which is probably related to staging T and chemotherapy，chemotherapy combined to radiotherapy maybe beneficial to local advanced staging T patients with nasopharyngeal carcinoma. 　　【Key words】 Nasopharyngeal carcinoma； Recurrent； Chemotherapy； Clinical factors 　　First-au