VEGF及其受体sFlt―1在妊娠期高血压疾病患者血清中变化及意义.docVIP

VEGF及其受体sFlt―1在妊娠期高血压疾病患者血清中变化及意义 　　【摘要】目的 探讨子痫前期患者血清中血管内皮生长因子（VEGF）及其可溶性受体l（sFlt-1）的水平及意义。方法 选择2011年8月至2012年3月在河北省沧州市中心医院产科分娩的子痫前期患者共60例（研究组），其中轻度子痫前期孕妇30例（轻度子痫前期组），重度子痫前期孕妇30例（重度子痫前期组），以同期正常晚期妊娠孕妇30例（对照组）。采用酶联免疫吸附试验法测定子痫前期患者孕晚期、临产前及产后血清VEGF及其sFlt-1水平，并与正常孕妇对照比较。结果 两组在孕晚期及临产前的VEGF、sFlt-1水平比较，差异均有统计学意义（P0.05）。结论 子痫前期患者血清中sFlt-1水平于孕晚期及临产前较正常孕妇明显增高，而VEGF水平降低，提示VEGF、sFlt-1可作为诊断子痫前期的指标之一。 　　【关键词】子痫前期；血管内皮生长因子；可溶性血管内皮生长因子受体l 　　Changes and Significance of Serum VEGF and sFlt-1 in Preeclampsia Pregnant Women 　　WU Guimei etal. （Department of Obstetrics and Gynecology， The Central Hospital of Cang Zhou，HeBei 061001，China） 　　【Abstract】Objective： To investigate the level of serum in VEGF and its receptor SFlt-1 in pregnant women with preeclampsia disease and the significance there of. Method： This study is to focus on 60 high blood pressure pregnant women （i.e. the study group） in the Central Hospital during August 8， 2011 through March， 2012， wherein the study involves 30 Preeclampsia women in early pregnancy， 30 Preeclampsia women in late pregnancy， and 30 regular women in late pregnancy （i.e. the contrast group）. The enzyme-linked immunosorbent assay（ELISA） is adopted to detect serum levels in VEGF and its sFlt-1 in women with Preeclampsia disease in every stages of pregnancy： early stage of pregnancy， late stage of pregnancy， pre-natal days， post-natal days. After that， the results of detection are compared to a group of regular women. Results：The results show differences in VEGF， SFlt-1 levels in late pregnancy stage and pre-natal stage of the two groups of pregnant women and the differences are statistically significant （P）. Conclusions：The conclusion of this study is that the level of sFlt-1 in serum of preeclampsia patient in late pregnant stage significant higher than the level of sFlt-1 in a regular pregnant women， whereas the VEGF level goes down. This shows that VEGF， sFlt-1 can be used as indicators for diagnosing a preeclampsia patient. 　　【key words 】 Pree