VEGF和Endostatin在乳腺癌中表达及其与临床病理特征相关性研究.docVIP

VEGF和Endostatin在乳腺癌中表达及其与临床病理特征相关性研究 　　(中山大学附属第五医院1.甲状腺、乳腺外科；2病理科 广东 珠海 519000)?? 　　【摘要】 目的: 研究分析血管内皮生长因子(VEGF)和内皮抑素 (Endostatin)在乳腺癌组织中的表达及其与临床病理参数的关系。 方法 采用免疫组织化学方法检测106例乳腺癌组织中VEGF和Endostatin的表达情况，分析VEGF和Endostatin与乳腺癌临床病理特征的关系及二者的相关性。 结果 VEGF和Endostatin在乳腺癌组织中的表达与有无淋巴结转移、组织分化程度和临床分期有关(P均＜0.05)，与患者年龄、绝经期、肿瘤T分期、M分期无关(P均＞0.05)。伴随着淋巴结转移、组织分化程度降低和临床分期的增加，癌组织中VEGF和Endostatin的表达显著升高，差异有统计学意义(P均＜0.05)。乳腺癌组织中VEGF和Endostatin的表达呈正相关(r＝0.594，P＜0.05)。 结论 VEGF和Endostatin的相互作用在乳腺癌细胞的侵袭和转移中起重要作用。? 　　【关键词】 乳腺癌；血管内皮生长因子；内皮抑素? 　　【中国分类号】 R735 　　【文献标识码】 【文章编号】1044-5511(2011)09-0017-02?? 　　【Abstract】 Objective To investigate the expression and clinical significance of VEGF and Endostatin in human breast cancer，and analyze molecular mechanisms of the invasion and metastasis of breast cancer. Methods The expression of VEGF and Endostatin in 106 specimens of breast cancer were detected by immunohistochemistry, and their correlations to the clinicopathologic characteristics of breast cancer were analyzed. The correlation of VEGF expression to Endostatin was analyzed by Spearman’s rank correlation. Results The expressions of VEGF and Endostatin had some relation with metastasis 、histological grade and clinical stages of breast cancer(P all＜0.05), but they had no correlation with age、menopause、T stages and M stages(P all＞0.05). Expressions of VEGF and Endostatin increased gradually with the progress of metastasis、histological grade and clinical stages(P all＜0.05). The positive correlation was observed between VEGF expression and Endostatin expression in breast cancer(r＝0.594，P＜0.05). Conclusion The interaction of VEGF and Endostatin may play an important role in regulation of the invasion and metastasis of breast cancer cell.? 　　【Key words】 Breast neoplasm；Vascular endothelial growth factor；Endostatin?? 　　 近年来的研究表明，血管内皮生长因子(vaseular endothelial growth factor，VEGF)和内皮抑素(endostatin)分别是目前已知的作用最强的血管生成促进因子和抑制因子[1]。我们应用免疫组织化学对106例乳腺癌患者组织标本进行VEGF和Endostatin蛋白的检测，探讨VEGF和Endostatin的表达与乳腺癌临床