COPD患者维生素D水平及其与炎症因子相关性研究.docVIP

COPD患者维生素D水平及其与炎症因子相关性研究 　　[摘要] 目的 探讨COPD患者的维生素D水平及其?c炎症因子的相关性研究。 方法 方便选取2012年5月―2014年5月于该院就诊的COPD患者106例为研究对象，据病情分为慢性阻塞性肺疾病急性发作期为A组53例、B组慢性阻塞性肺疾病稳定期53例，C组53名健康人，行CAT测试，通过ELISA检测3组的25-（OH）D、INF-r、IL-17水平，比较3组之间的相关性。 结果 A组维生素D总缺乏率83.01%高于B组缺乏率81.13%和C组缺乏率5.66%，差异有统计学意义（P0.05）；3组血清25-（OH）D水平C组（78.89±53.12）ng/mL高于A组（18.86±15.06）ng/mL、B组（37.76±17.96）ng/mL，3组INF-r、IL-17水平A组（57.11±11.02）、（289.88±94.76）pg/mL大于B组（36.69±5.47）、（103.15±43.28）pg/mL，C组（26.23±2.14）、（52.03±5.36）pg/mL，比较结果差异有统计学意义（P0.05）。 结论 COPD患者的维生素D水平及其与炎症因子有相关性，预防改善患者生活质量。 　　[关键词] COPD；维生素D水平；炎症因子；相关性 　　[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2017）12（a）-0027-03 　　[Abstract] Objective To study the vitamin D level of COPD patients and correlation with inflammatory factors. Methods 106 cases of COPD patients diagnosed in our hospital from May 2012 to May 2014 were convenient selected and divided into three groups with 53 cases in each， the group A were patients with chronic obstructive pulmonary diseases acute attack phase， the group B were patients with chronic obstructive pulmonary diseases in the steady phrase， and the group C were health people， underwent the CAT test， and the 25-（OH） D，INF-r， IL-17 levels of the three groups were tested by the ELISA. Results The total deficiency rate of vitamin D in the group a was higher than that in the group B and in the group C，（83.01% vs 81.13%，5.66%）， and the difference was statistically significant（P0.05）， and the serum 25-（OH）D level in the group C was higher than that in the group A and in the group B[（78.89±53.12）ng/mL vs （18.86±15.06）ng/mL vs （37.76±17.96）ng/mL]， and the INF-r and IL-17 levles in the group A were higher than those in the group B and in the group C[（57.11±11.02）， （289.88±94.76）pg/mL vs （36.69±5.47），（103.15±43.28）pg/mL vs （26.23±2.14），（52.03±5.36）pg/mL]， and the differences were statistically significant（P0.05）. Conclusion The vitamin D level of COPD patients is correlated with the inflammatory factor， and we should prevent and improve the quality