Ki67GFAP在人脑恶性胶质瘤病理分级中意义.docVIP

Ki67GFAP在人脑恶性胶质瘤病理分级中意义 　　[摘要] 目的 探讨Ki67、GFAP与人脑恶性胶质瘤病理分级的关系。 方法 取深圳市宝安区中医院病理科2007年1月~2012年12月组织学确诊为恶性胶质瘤标本31例，根据WHO（2007年）胶质瘤分级标准，分为胶质瘤Ⅱ级组、胶质瘤Ⅲ级组和胶质瘤Ⅳ级组，另取10名正常人脑组织胶质细胞作为正常对照组。免疫组织化学法检测Ki67及GFAP表达。 结果 Ki67表达水平在正常对照组最低，随着肿瘤WHO分级的增高而增高，在胶质瘤Ⅳ级组达高峰，差异有统计学意义（P 0.05）；GFAP表达水平在正常对照组最高，随WHO分级的增高而降低，在胶质瘤Ⅳ级组表达水平最低，差异有统计学意义（P 0.05）。 结论 Ki67、GFAP可作为人脑恶性胶质瘤病理分级及预后判断有价值的参考指标。 　　[关键词] 胶质瘤；Ki67；GFAP 　　[中图分类号] R73-3[文献标识码] A[文章编号] 1673-7210（2014）06（c）-0031-04 　　 　　Significance of Ki67, GFAP in human brain m alignant glioma of different pathological grading 　　CHEN Meihua1 CHEN Guizhen1 JIA Wanjun1 ZOU Guihua2 　　1.Department of Pathology, Hospital of TCM in Baoan District of Shenzhen City, Guangdong Province, Shenzhen 518100, China; 2.Department of Pathology, the Peoples Hospital of Baoan District in Shenzhen City, Guangdong Province, Shenzhen 518100, China 　　[Abstract] Objective To study the correlation betweem Ki67, GFAP expression and pathological grading of human brain m alignant glioma. Methods 31 cases of m alignant glioma specimens confirmed by histology in Hospital of TCM in Baoan District of Shenzhen City were collected from January 2007 to December 2012, while divided into glioma Ⅱ, Ⅲ and Ⅳ grade groups according to WHO (2007) glioma grading standards. Another 10 cases of normal brain tissues were selected as control group. Then the expression of Ki67, GFAP was detected by immunohistoehemistry. Results The expression of Ki67 in normal control group was the lowest, which increased with the increase of WHO grading of tumors, reached a peak in glioma Ⅳ grade group, the difference was statistically significant (P 0.05). The expression level of GFAP in normal control group was the highest, which decreased with the increase of WHO grading of tumors, reached a bottom in glioma Ⅳ grade group, the difference was statistically significant (P 0.05). Conclusion Ki67 and GFAP can be regarded as valuable markers to judge the pathological grading and prognosis. 　　[Key words]