Livin和Survivin在尖锐湿疣组织中表达和意义.docVIP

Livin和Survivin在尖锐湿疣组织中表达和意义 　　【摘要】目的：探讨凋亡抑制蛋白Livin和Survivin在尖锐湿疣(CA)组织中的表达及意义。方法：采用免疫组化SP法分别检测Livin和Survivin蛋白在56例CA组织和18例正常上皮组织中的表达。结果：尖锐湿疣组织中Livin和Survivin蛋白阳性表达率分别为82.14%(46/56)、85.71%(48/56)，正常人对照组分别为22.22%(4/18)、38.89%(7/18)；尖锐湿疣组织中Livin和Survivin蛋白阳性表达强度多为(++)~(+++)，正常对照组多为(-)~(++)。两组Livin和Survivin阳性表达率及表达强度差异均具有统计学意义(P0.05)。尖锐湿疣组织中Livin和Survivin表达呈负相关(r=-0.634，P0.01)。结论：尖锐湿疣组织中存在Livin和Survivin过表达，Livin和Survivin的过表达可能对尖锐湿疣的发生发展有一定作用。 　　【关键词】Livin；Survivin；尖锐湿疣；免疫组化 　　 　　Expression and Significance of Livin and Survivin Protein in Keratinocytes of Condyloma Acuminatum/ZHAO Wei-hua， XIA Yong-hua，XIE Shi-hai，et al.//Medical Innovation of China，2012，9(11)：001-002 　　【Abstract】Objective：To explore expression and significance of Livin and Survivin protein in keratinocytes of condyloma acuminatum(CA)， and their roles.Methods：The expressions of Livin and Survivin were analyzed by immunocytochemical stainwithstreptavidin．Pemxidase (SP)in tissue specimens from the lesions of 56 patients with CA and foreskin of 18 normal human controls．Results：The detection rates of Livin and Survivin were 82.14%(46/56) and 85.71%(48/56) in CA lesions，respectively，compared to 22.22%(4/18) and 38.89%(7/18) in the controls，respectively.The expressions of Livin and Survivin varied from positive (++) to strongly positive (+++) in CA lesions，and from negative(-) to positive(++) in the controls(both P0.05)．There is negative correlation between the expression of Livin and Survivin in CA lesions(r =-0.634，P0.01)．Conclusion：There is an overexpression of Livin and Survivin in CA tissue．which may be involved in the occurrence and development of CA． 　　【Key words】Livin；Survivin；Condyloma acuminatum；Immunohistochemistry 　　First-author’s address： The Dermatology Hospital of Huizhou， Huizhou 516008，China 　　doi：10.3969/j.issn.1674-4985.2012.11.001 　　尖锐湿疣(condyloma acuminatum，CA)是发病率排名第二的性传播疾病，临床上CA增生快，治疗后常易复发。虽是一种良性增生性疾病，但部分可发展为巨大CA(又称Buschke-loewenstein肿瘤)，且有潜在癌变的可能性，这可能与CA组织中存在凋亡相关基因的异常表达有关。Sur