α 硫辛酸对糖尿病周围神经病变氧化应激及脉搏波传导速度影响.docVIP

α 硫辛酸对糖尿病周围神经病变氧化应激及脉搏波传导速度影响 　　【摘要】 目的 观察α硫辛酸（ALA）对糖尿病周围神经病变（DPN）的氧化应激及脉搏波传导速度的影响。 　　方法 将83例2型糖尿病并发 DPN 的患者随机分为两组，观察组43例，给予ALA 600 mg，加入100 ml生理盐水中避光静脉滴注，每日1次；对照组40例，给予甲钴胺500 μg肌肉注射1次/d，两组均连续治疗2周。治疗前后检测两组患者血清丙二醛（MDA）水平和超氧化物歧化酶（SOD）水平，并进行脉搏波传导速度（PWV）测定。 　　结果 与治疗前相比，对照组SOD显著升高，PWV显著下降（P005），观察组SOD显著升高，MDA、PWV显著下降（P0.01）；与对照组比较，治疗后观察组的SOD、MDA及PWV较对照组改善更为明显（P005或0.01）。 　　结论 ALA能减轻DPN 患者的氧化应激，改善动脉僵硬度。 　　【关键词】 α硫辛酸；丙二醛；超氧化物歧化酶；脉搏波传导速度；糖尿病周围神经病变 　　中图分类号： R587.2 文献标识码：A 文章编号2014 　　DOI：10.3969/j.issn2014.02.012 　　Influence of αlipoic acid on oxidative stress and pulse wave velocity of diabetic peripheral neuropathy 　　[HJ2][HJ] 　　HUANG Hong，YANG Pijian，LI Shumin，LV Yipei 　　（Department of Endocrinology，the Second Peoples Hospital of Qinzhou，Qinzhou 535000，Guangxi，China） 　　[HJ2][HJ] 　　【Abstract】 Objective To observe the influence of αlipoic acid （ALA） on the oxidative stress and pulse wave velocity of diabetic peripheral neuropathy （DPN）. 　　Methods 83 patients with type 2 diabetes and DPN were randomly divided into the observation group（43 cases） and the control group （40 cases）.The observation group was given 600 mg of ALA which was added to 100 ml of saline and taken by patients by intravenous drip once a day.The control group was given 500 μg of mecobalamine once a day by intramuscular injection.Both groups were treated for 2 weeks in succession.Then，the serum level of methane dicarboxylic aldehyde（MDA） and superoxide dismutase（SOD） before and after treatment in both groups were tested，and the pulse wave velocity（PWV）was measured. 　　Results Compared with those before treatment，the SOD level of the control group significantly increased after treatment， while their PWV decreased significantly（P005）.In addition，the SOD，MDA and PWV of the observation group improved more significantly than those of the control group（P005 or 001）. 　　Conclusion ALA can alleviate oxidative stress and improve arterial stiffness of DPN patients. 　　【Key w