CYSC和RBP联合测定在肿瘤化疗患者早期肾损伤监测中临床应用.docVIP

CYSC和RBP联合测定在肿瘤化疗患者早期肾损伤监测中临床应用 　　[摘要] 目的 探讨血清半胱氨酸蛋白酶抑制剂C（Cysc）与视黄醇结合蛋白（RBP）两者联合起来对肿瘤化疗患者早期肾损伤监测中的测定效果与临床疗效。方法 随机选择2012年1月―2013年2月参与该研究的60例健康体和肿瘤化疗患者，将分为研究组与对照组，研究组为肿瘤化疗患者，对照组为健康体质，并经过检查，没有出现肾脏病史。另外，还对所有患者进行Cysc、RBP、BUN以及Crea等方面的检测，对比分析两组患者的临床检测指标。结果 研究组的Cysc、RBP、BUN以及Crea浓度，每一项都明显高于对照组，差异有统计学意义（P0.05）。结论 Cysc与RBP两者联合，对肿瘤化疗患者早期肾损伤进行监测，具有重大的临床意义，提高临床疗效，值得推广。 　　[关键词] Cysc；RBP；肾损伤；肿瘤化疗 　　[中图分类号] R473.73 [文献标识码] A [文章编号] 1674-0742（2014）03（b）-0034-02 　　[Abstract] Objective To investigate the determination effect of serum cystatin C（Cysc）binding protein and retinol（RBP）for the monitoring of early renal injury in cancer patients undergoing chemotherapy and its clinical curative effect.Methods From January， 2012 to February， 2013， 60 healthy subjects and tumor patients undergoing chemotherapy were randomly selected and enrolled in this study. And they were divided into the study group consisting of tumor patients undergoing chemotherapy， and the control group consisting of healthy people with no history of kidney disease after physical examination.In addition，Cysc，RBP，BUN and Crea of all patients were detected. The clinical indexes of two groups of patients were compared and analyzed.Results The Cysc， RBP， BUN and Crea concentration of the study group is significantly higher than that of the control group， respectively，the differences between two groups were statistically significant （P0.05）.Conclusion The determination of Cysc and RBP in the monitoring of early renal injury in cancer patients undergoing chemotherapy has important clinical significance， which can improve the clinical efficacy， and is worthy of promotion. 　　[Key words] Cysc； RBP； Renal injury； Tumour chemotherapy 　　随着科学技术的发展，人们生活水平不断提高，对健康也越来越关注，但是近年来，肿瘤化疗的患者人数在不断增多。给予肿瘤患者进行早期治疗，可有效提高化疗患者的生活质量。 为探讨血清半胱氨酸蛋白酶抑制剂C（Cysc）与视黄醇结合蛋白（RBP）两者联合起来对肿瘤化疗患者早期肾损伤监测中的测定效果与临床疗效，该研究给予2012年1月―2013年2月参与的60例健康体和肿瘤化疗患者，均给予进行Cysc、RBP等各方面的检测，现报告如下。 　　1 资料与方法 　　1.1 一般资料 　　随机选择参与该研究的60例健康体和肿瘤化疗患者，其中男35例，女28例，将所有参与研究的对象，分为研究组