EGFR与VEGF在三阴性乳腺癌中表达及意义.docVIP

EGFR与VEGF在三阴性乳腺癌中表达及意义 　　[摘要] 目的 探讨表皮生长因子受体（EGFR）与血管内皮生长因子（VEGF）在三阴性乳腺癌中的表达及临床意义。方法 选择2014年1月～2016年12月在我院手术切除的三阴性乳腺癌标本52例为观察组，另选择同期在我院手术治疗的非特殊类型乳腺浸润性导管癌标本50例为对照组。检测两组标本中EGFR与VEGF的阳性率，分析三阴性乳腺癌患者的年龄、临床分期、淋巴?Y转移、肿瘤大小等与EGFR及VEGF阳性率的关系。 结果 观察组VEGF阳性率、EGFR阳性率均显著高于对照组，差异有统计学意义（P0.05）；临床分期Ⅲ-Ⅳ期的EGFR阳性率显著高于Ⅰ-Ⅱ期，差异有统计学意义（P0.05）；有淋巴结转移组织的VEGF阳性率显著高于无淋巴结转移组织，差异有统计学意义（P0.05）。 结论 三阴性乳腺癌组织中EGFR与VEGF阳性表达率增加，且与肿瘤的发展密切相关。 　　[关键词] 表皮生长因子受体；血管内皮生长因子；三阴性乳腺癌；表达 　　[中图分类号] R737.9 [文献标识码] A [文章编号] 1673-9701（2017）14-0032-03 　　[Abstract] Objective To investigate the expression and clinical significance of EGFR and VEGF in triple negative breast cancer. Methods A total of 52 cases of triple-negative breast cancer specimen surgically resected in our hospital from January 2014 to December 2016 were selected as the observation group， and 50 cases of non-special type breast invasive ductal carcinoma specimen surgically resected in our hospital in the same period were chosen as the control group. The positive rates of EGFR and VEGF in the two groups were detected. The relationship between the age， clinical stage， lymph node metastasis， tumor size and the positive rate of EGFR and VEGF was analyzed in triple negative breast cancer patients. Results The positive rate of VEGF and the positive rate of EGFR in the observation group were significantly higher than those in the control group（P0.05）. The positive rate of EGFR in clinical stage Ⅲ-Ⅳ was significantly higher than that in stage Ⅰ-Ⅱ， and the difference was statistically significant（P0.05）. The positive rate of VEGF in patients with lymph node metastasis was significantly higher than that in patients without lymph node metastasis， and the difference was statistically significant（P0.05）. Conclusion The positive expression rate of EGFR and VEGF in triple negative breast cancer tissue is increased and closely related to the development of tumor. 　　[Key words] Epidermal growth factor receptor； Vascular endothelial growth factor； Triple-negative