Pgp在口腔鳞状细胞癌中表达及临床病理意义.docVIP

Pgp在口腔鳞状细胞癌中表达及临床病理意义 　　【摘要】目的 研究肿瘤耐药相关基因P－糖蛋白（P-gp）在口腔鳞状细胞癌组织中的表达及其与临床病理特征和预后的关系。方法 应用免疫组化S-P法检测口腔鳞状细胞癌组织76例及正常粘膜组织30例，观察肿瘤耐药相关基因P-gp的表达，同时回顾性研究了这些表达与口腔鳞状细胞癌发生、浸润及转移等临床病理学参数的关系。结果 （1）口腔鳞状细胞癌组织中，P-gp的表达阳性率分别为：88.16％。30例正常粘膜组织中，表达率为60%。差异均有统计学意义（P0.05）。（2）口腔鳞状细胞癌组织中，P-gp在不同临床分期、不同浸润深度组之间阳性表达率的差异有统计学意义（P0.05）。结论 P-gp在肿瘤的多药耐药中起一定的作用。P-gp在口腔鳞癌的发生发展中可能有协同作用。检测P-gp的表达对口腔鳞癌化疗方案的制定、判断预后有重要的指导意义。 　　【关键词】口腔鳞状细胞癌 P－糖蛋白 　　中图分类号：R739.8 文献标识码：B 文章编号：1005-0515（2011）5-054-03 　　The Expression of P-gp in oral squamous cell carcinoma and their clinical Pathology Significance 　　Zhao Lingbing1 Pu Hongwei2 Wang Ye2 Li Xiaomei2 　　（1. Department of Oral, the Second People Hospital of Changji ， Xinjiang Changji 831100, China; 　　2. Vocational and Technical College, Xinjiang Medical University，XinjiangUrumqi830011, China） 　　【Abstract】Objective To investigate clinical pathology significance and expression of P-gp in oral squamous cell carcinomant. Methods Envision immunohistochemical method was used to detect the expressions of P-gp in 76 cases of oral squamous cell carcinoma and in 30 cases of normal tissues, and to analyse the relationship between them and different clinical pathological factors. Results (1) The positive frequency of P-gp in oral carcinoma tissues is separately 88.16％，the positive frequency of them in normal tissues is 60%. The differences has statistically significant (P0.05). (2) In different clinical stages and different depth of invasion of oral carcinoma the positive frequency of P-gp protein have statistically significant (P0.05). ConclusionIt is suggested that P-gp plays an important role in multidrug resistance. Examining P-gp expression in oral squamous cell carcinoma, plays an important role in orientating the cancer treatment and predicting prognosis. 　　【Key words】 oral squamous cell carcinoma; P-gp 　　 　　口腔鳞状细胞癌（oral squamous cell carcinoma，OSCC）是口腔颌面部最常见的恶性肿瘤，侵袭和转移是造成患者死亡的主要原因，而颈部淋巴结则是最常见的转移靶器官[1] 。肿瘤细胞的多药耐药性是肿瘤主要原因之一。近年来对口腔癌多药耐药的研究不断深入，为临床评价和预测化疗效果，及