rhBNP早期应用对急性ST段抬高型心肌梗死患者支架植入术后冠脉血流及近期预后影响.docVIP

rhBNP早期应用对急性ST段抬高型心肌梗死患者支架植入术后冠脉血流及近期预后影响 　　摘要：目的探讨对于急性ST段抬高型心梗（STEMI）患者，早期应用rh-BNP（重组人脑利钠肽）对患者支架植入术后冠脉血流及近期预后的影响。方法入选沈阳医学院附属第二医院2013年3月~2014年3月急性STEMI并行PCI治疗的患者100例，其中，男性59例，女性41例，平均年龄(57.8±7.1)岁，随机分组（rh-BNP早期应用组,即试验组n=50例）与（常规组，即对照组，n=50例）的临床资料进行分析。结果试验组与对照组相比，PCI术中无复流及慢血流的发生率明显低于对照组，（P＜0.05）;住院期间的主要心血管事件发生率试验组明显低于对照组，（P＜0.05）。结论对于急性STEMI患者，尽早应用rh-BNP（重组人脑利钠肽）可以明显降低PCI术中无复流及慢血流的发生率，明显降低（MACE）的发生率。 　　关键词：心肌梗死；重组人脑利钠肽；经皮、经腔冠状动脉介入治疗 　　Intracoronary Flow Influence of Early Use of Lyophilized Recombinant Human Brain Natriuretic Peptide(rh-BNP) in Patients with Acute STEMI after Intracoronary Stenting Use and Short-term out Comes 　　TAN Li-li,LIU Li-min*,LI Lu,ZHAO Hong-li,MA Jing-ru ,JIN Xia ,ZHOU Xue 　　(Deparment of Cardiology,The Second Hospital Affiliated to Shenyang Medical Colledge, Shenyang 110035,Liaoning,China) 　　Abstract：ObjectiveTo study intracoronary flow influence of early use of Lyophilized Recombinant Human Brain Natriuretic Peptide(rh-BNP) in patients with STEMI after intracoronary stenting use and short-term out comes. MethodsOne hundred STEMI patients(59 males,41 females,mean age 57.8±7.1 years old) admitted during March,2013 to March 2014 were include in the study from shenzhou Hospital of Shenyang Medical College. The patients were divided into the early use rh-BNP group (n=50) and the conventional medical treatment group (n=50). Clinical data analysis.ResultsThe incidence of slow-flow and no-reflow of the early use rh-BNP group was lower than that of the conventional medical treatment group (P＜0.05);the rate of MACE was all lower than that of common use rh-BNP group(P＜0.05). ConclusionEarly use of Lyophilized Recombinant Human Brain Natriuretic Peptide(rh-BNP)patient with STEMI is feasible and can reduce not only the rate of no-reflow, but also slow flow and MACE during operation. 　　Key words：Myocardial infarction；Lyophilized Recombinant Human Brain Natriuretic Peptide(rh-BNP)；Percutaneous,transluminal coronary injection 　　急性ST段抬高性心肌梗死是造成心源性