HIF―1α和HIF―2α在高原藏族胃癌中表达及其意义.docVIP

HIF―1α和HIF―2α在高原藏族胃癌中表达及其意义 　　[摘要] 目的 探讨HIF-1α和HIF-2α在高原藏族胃癌中的表达及其意义。方法 整群选取2013年4月―2014年4月该院收治的40例胃癌患者资料进行分析，将其设置为实验组，选择同期入院的40例非胃癌患者作为对照组，采用免疫组化SP法检测入选患者组织中的HIF-1α和HIF-2α以及VEGF表达，分析其在高原藏族胃癌中的表达及其意义。结果 胃癌患者HIF-1α阳性表达率62.5%，显著高于对照组（P0.05）；VEGF表达和淋巴结转移、浸润深度以及临床TNM分期关系密切（P0.05）。 结论 HIF-1α和HIF-2α因子的表达和高原藏族胃癌的发生和发展具有紧密的联系，治疗时加强低氧诱导因子监测，可能对临床治疗方案具有一定的指导意义。 　　[关键词] HIF-1α；HIF-2α；高原藏族胃癌；表达 　　[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2015）10（a）-0072-03 　　Expression of HIF-1α and HIF-2α in Tibetan Plateau Patients with Gastric Cancer and Its Significance 　　LIU Ke1， ZHU Min-xia2， CAI Peng2， LIU Xiao-li2 　　1.Department of General Surgery， General Hospital of Tibet Military Area Command， Lhasa， Tibet Autonomous Region， 850000 China；2. Life Science Laboratory， Tibetan Ethnic University， Xianyang， Shaanxi Province， 712082 China 　　[Abstract] Objective To investigate the expression of HIF-1αand HIF-2α in tibetan plateau patients with gastric cancer and its significance. Methods 40 patients with gastric cancer admitted to the hospital between April 2013 and April 2014 were assigned to the observation group and other 40 people without gastric canner in the same period were assigned to the control group. The expression of HIF-1α and HIF-2α and VEGF in gastric cancer tissue was determined using immunohistochemical SP method， and its significance was analyzed. Results The HIF-1α-positive rate， HIF-2α-positive rate and VEGF-positive rate were 62.5%， 37.5%， 65% respectively in the observation group， all significantly higher than those in the control group， P0.05； there were close correlation between the expression of VEGF and lymph node metastasis， depth of invasion and clinical TNM staging， P0.05）. Conclusion The expression of HIF-1α and HIF-2α are closely related to the occurrence and development of gastric cancer in tibetan plateau patients. Strengthening monitoring on hypoxia inducible factor may have some significance for clinical treatment. 　　[Key words] HIF-1α； HIF-2α； Gastri