IL―17在重症肺炎患者外周血中临床表达意义研究.docVIP

IL―17在重症肺炎患者外周血中临床表达意义研究 　　[摘要]目的 分析IL-17在重症肺炎患者外周血中的临床表达意义。方法 选取2015年1月～2016年1月医院收诊的100例重症肺炎患者为观察组，并根据患者的急性生理学与慢性健康状况评分Ⅱ（APACHEⅡ评分）分为A组（APACHEⅡ评分20分）和B组（APACHEⅡ评分≤20分），再选取2015年1月～2016年1月的100例健康体检者为对照组。三组均行体温（T）、白细胞（WBC）计数、降钙素原（PCT）、血乳酸（Lac）、白细胞介素-17（IL-17）等的检查，并比较检查结果的差异。结果 A、B组的T、WBC、PCT、Lac、IL-17均显著高于对照组，差异有统计学意义（P0.05）；A、B组的I-17比较差异有统计学意义（P0.05）。结论 重症肺炎患者的IL-17水平显著高于健康人群，且随着病情的加重会升高，提示IL-17水平升高能够反映患者的病情。 　　[关键词]白细胞介素-17；外周血；重症肺炎 　　[中图分类号] R563.1 [文献标识码] A [文章编号] 1674-4721（2017）11（a）-0017-03 　　Study of clinical expression significance of IL-17 in peripheral blood of patients with severe pneumonia 　　CAI Bi-lin LIN Gui-hua XIE Hua-wen CHEN Jun CHEN Ming-di ZENG Wen-chi 　　Department of Critical Care Medicine，the Second Affiliated Hospital of Guangdong Medical University，Zhanjiang 524000，China 　　[Abstract]Objective To analyze the clinical expression significance of IL-17 in peripheral blood of patients with severe pneumonia.Methods A total of 100 patients diagnosed as severe pneumonia from January 2015 to January 2016 were selected in our hospital.According to the acute physiology and chronic health evaluation Ⅱ （APACHEⅡ），they were divided into group A （APACHEⅡ score20 points） and group B （APACHE Ⅱ score ≤20 points）.Another group of 100 healthy people after physical examinations from the same period was chosen as control group.The body temperature （T），white blood cell （WBC） count，procalcitonin （PCT），blood lactic acid （Lac），and interleukin-17 （IL-17） were all tested among three groups.The difference of these outcomes were compared.Results T，WBC，PCT，Lac，and IL-17 in group A and B were much higher than those in the control group with statistical differences （P0.05），but with regard to IL-17，there was a statistical difference （P0.05）.Conclusion IL-17 in patients with severe pneumonia is significantly higher than that in the healthy，and the level increases with the exacerbation of disease conditions，which indicates that increase of IL-17 level can reflect the condi