不同剂型黄体酮治疗功能性子宫出血临床效果及药物经济学评价.docVIP

不同剂型黄体酮治疗功能性子宫出血的临床效果及药物经济学评价 　　[摘要] 目的 探讨不同剂型黄体酮治疗功能性子宫出血的临床效果及药物经济学评价。 方法 选择本院2012年7月～2013年7月收治的114例功能性子宫出血患者，随机分为观察组、实验组和对照组各38例，对照组患者采用黄体酮阴道凝胶治疗，实验组患者采用黄体酮胶囊治疗，观察组患者采用黄体酮栓治疗。对比分析3组的治疗效果及药物经济学评价。 结果 观察组和对照组总有效率高于实验组，差异有统计学意义（P0.05）。观察组成本-效果比为76.69，实验组为322.04，对照组1547.71，实验组与对照组相对于观察组的增量成本-效果比分别为-1015.5、19 748.61。 结论 黄体酮栓治疗功能性子宫出血的临床效果明显，经济学指标最佳，具有临床应用价值。 　　[关键词] 黄体酮胶囊；黄体酮栓；黄体酮阴道凝胶；功能性子宫出血 　　[中图分类号] R711.52 [文献标识码] A [文章编号] 1674-4721（2015）01（b）-0121-03 　　Clinical effect of different dosage form progestin in treatment of dysfunctional uterine bleeding and pharmacoeconomics evaluation 　　ZHANG Wei 　　Department of Obstetrics and Gynecology，Maternity and Child Care of Xi County in Xinyang City of Henan Province，Xi County 464300，China 　　[Abstract] Objective To explore the efficacy and safety of different dosage form progestin in treatment of dysfunctional uterine bleeding and pharmacoeconomics evaluation. Methods 114 cases of patients with dysfunctional uterine bleeding treated in our hospital from July 2012 to July 2013 were selected，and were randomly divided into observation group，experimental group and control group，38 cases in each group，control group were taken with progesterone vaginal gel，experimental group were taken with progesterone suppository，observation group were taken with progesterone capsules.The effect of three groups and pharmacoeconomics evaluation was analyzed. Results The total effective rate of observation group and control group was higher than that of experimental group，the difference was significant （P0.05）.The cost-effectiveness ratio of observation group，experimental group and control group was 76.69，322.04 and 1547.71，respectively.The increment of cost-effectiveness of experimental group and control group was -1015.5 and 19 748.61. Conclusion Progesterone suppository has best effect in treatment of dysfunctional uterine bleeding，has clinical application value. 　　[Key words] Progesterone capsules；Progesterone capsules；Progesterone vag