依那普利、美托洛尔联合治疗慢性心力衰竭的临床观察.docVIP

依那普利、美托洛尔联合治疗慢性心力衰竭的临床观察 　　[摘要] 目的 探讨依那普利、美托洛尔联合治疗慢性心力衰竭的临床应用效果。 方法 选取2014年6月～2016年6月我院住院治疗的慢性心力衰竭患者80例作为研究对象，随机分为两组，每组40例。对照组采取常规强心、利尿、扩血管等强心治疗，观察组同时予以依那普利、美托洛尔联合进行治疗，6个月为一个疗程。 若有心绞痛或心肌缺血者应用硝酸酯类药物治疗。 治疗半年后观察患者的心功能左室射血分数（LVEF）的变化情况，并对两组的临床疗效进行对比分析。 结果 观察组患者的总有效率显著高于对照组，差异具有统计学意义（P0.05）。观察组患者治疗后的LVEF 较对照组显著提高，差异具有统计学意义（P0.05）。 结论 对于慢性心力衰竭患者在常规强心、利尿、扩血管等强心治疗的基础上同时予以依那普利、美托洛尔联合进行治疗，可以显著提高临床疗效，且明显改善患者的心功能，从而有利于提高患者的生活质量，促进疾病尽快恢复。 　　[关键词] 慢性心力衰竭；依那普利；美托洛尔；联合治疗 　　[中图分类号] R541.6 [文献标识码] B [文章编号] 1673-9701（2017）09-0056-03 　　Clinical observation of enalapril and metoprolol in the treatment of chronic heart failure 　　DU Weiyuan 　　Department of Cardiology， Changle County Peoples Hospital in Shandong Province，Changle 262400， China 　　[Abstract] Objective To investigate the clinical effect of enalapril and metoprolol in the treatment of chronic heart failure. Methods 80 patients with chronic heart failure treated in our hospital from June 2014 to June 2016 were randomly divided into two groups， 40 cases in each group. The control group was treated with conventional cardiac， diuretic， vasodilator and other cardiac therapy， the observation group was treated with enalapril and metoprolol， 6 months as a course of treatment. Patients with angina pectoris or myocardial ischemia were treated with nitrates. The changes of left ventricular ejection fraction（LVEF） were observed after treatment six months， and the clinical efficacy was compared between two groups. Results The total effective rate of the observation group was significantly higher than that of the control group， the difference was statistically significant（P0.05）. The LVEF of the observation group after treatment was significantly higher than that of the control group， the difference was statistically significant（P0.05）. Conclusion For patients with chronic heart failure on the basis of conventional cardiac， diuretic and vasodilator therapy on cardiac combind enalapril and metoprolol treatment， can significantly impro