中医辨证治疗Ⅲ型前列腺炎疗效及机制探讨.docVIP

中医辨证治疗Ⅲ型前列腺炎的疗效及机制探讨 　　【基金项目】广东省佛山市科技局医学类科技攻关项目（201308282）。 　　【第一作者简介】余南生(1979-)，男，主治医师，主要研究方向为皮肤病性病及男科学 　　DOI:10.3969/j.issn.1672-1993.2014.07.019 　　【摘要】目的:观察中医辨证治疗Ⅲ型前列腺炎的临床疗效并探讨其可能的作用机制。方法:将80例Ⅲ型前列腺炎患者，随机分为辨证治疗组和对照组各40例。治疗组予中医辨证分型治疗；对照组予巴洛沙星片、塞来昔布胶囊和盐酸坦洛缓释片治疗。观察患者治疗前后的NIH-CPSI评分、症状复发情况和治疗前后细胞因子水平的变化，以及复发者细胞因子水平变化。结果:治疗完成后总有效率差异无统计学意义（P＞0??05），辨证组复发率显著低于对照组（P＜0??01）；治疗前，两组患者IL-8、M-CSF、TNF-α均高于健康者，IL-10低于健康者，治疗后两组血清IL-8、M-CSF、TNF-α水平均有升高，两组间比较差异有显著统计学意义（P＜0??01），两组血清IL-10水平升高，两组间比较差异有显著统计学意义（P＜0??01）。结论:中医辨证治疗慢性前列腺炎安全有效，复发率低，其机制可能是通过调节免疫功能来实现；细胞因子水平变化能及时、准确反映疾病转归。 　　【关键词】Ⅲ型前列腺炎；中医辨证治疗；细胞因子 　　Effect and mechanism of traditional Chinese medicine in treating chronic prostatitis ⅢYU Nansheng1, GAO Xianglin2, LIANG Donglong1, YANG Lizhen1, XIE Lihao1, DENG Shuhuan3. 1. Department of Dermatology, Lecong Hospital of Shunde, Foshan 528315, China； 2. Department of Dermatology, Lecong Hospital of Shunde, Foshan 528315, China； 3. Department of Dermatology, Lecong Hospital of Shunde, Foshan 528315, China 　　【Abstract】Objectives: To study the effect of traditional Chinese medicine (TCM) on Chronic Prostatitis Ⅲ and its possible mechanism. Methods: 80 patients with Chronic Prostatitis Ⅲ were randomly divided into two groups. The treatment group (40cases) was treated with TCM and the control group (40cases) was treated with Balofloxacin Tablets, Celecoxib Capsules and Tamsulosin Hydrochloride Sustained Release Tablets. The NIH-CPSI scores and recurrence of symptoms and cytokine levels before and after the treatment was compared and analyzed. Results: There was no significant difference in total effective rateafter the treatment (P＞0.05) but the relapse rate of treatment group was significantly lower than control group (P0.01); the levels of serum IL-8, M-CSF and TNF-α increased after treatment as well as levels of serum IL-10, with significant differences between the two groups（P＜0.01). Conclusion: TCM is efficient and safe in treating patients with Chronic Prostatitis Ⅲ wi