二甲双胍干预对乳腺癌化疗伴糖代谢异常患者血糖影响.docVIP

二甲双胍干预对乳腺癌化疗伴糖代谢异常患者血糖的影响 　　[摘要] 目的 研究二甲双胍干预对乳腺癌化疗伴糖代谢异常患者血糖的影响。方法 整群选择2012年2月―2014年8月来该院行乳腺癌化疗，伴糖代谢紊乱的60例患者作为研究对象，随机分为两组。对照组给予AC-T化疗方案，同时给予患者饮食控制和运动治疗，观察组在对照组基础上加用二甲双胍，观察两组血糖控制情况。结果 观察组化疗结束时和化疗结束后3个月正常血糖患者例数显著多于对照组，差异具有统计学意义（P0.05）。 结论 二甲双胍对于控制乳腺癌化疗伴糖代谢紊乱患者血糖水平效果显著，且具有潜在抗肿瘤作用，值得进一步研究。 　　[关键词] 二甲双胍；乳腺癌；糖代谢紊乱；环磷酰胺 　　[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2016）01（b）-0127-02 　　Effect of Metformin Intervention on Blood Sugar of Patients with Breast Cancer Chemotherapy with Abnormal Glucose Metabolism 　　ZHAI Yuan-yuan 　　mammography department，The Second Affiliated Hospital of Zhengzhou University， 450000 China 　　[Abstract] Objective To research the effect of metformin intervention on blood sugar of patients with breast cancer chemotherapy with abnormal glucose metabolism. Methods 60 cases of patients with breast cancer chemotherapy with abnormal glucose metabolism in our hospital from February 2012 to August 2014 were selected as the research object and randomly divided into two groups， the control group received AC-T chemotherapy plan， and were treated with diet control and exercise， the observation group were given additional metformin on the basis of the control group， the blood sugar control conditions of the two groups were observed. Results The case number of patients with normal blood sugar at the end of chemotherapy and in 3 months after chemotherapy in the observation group was obviously more than that in the control group， and the difference was statistically significant （P0.05）. Conclusion Metformin for controlling the blood sugar levels of patients with breast cancer chemotherapy with abnormal glucose metabolism has an obvious effect and has a potential anti-tumor effect， which is further research. 　　[Key words] Metformin；Breast cancer；Abnormal glucose metabolism；Cyclophosphamide 　　乳腺癌是威胁女性健康最常见的恶性肿瘤之一，发病率有逐年上升的趋势，据相关资料显示，乳腺癌的发病率占全身各种恶性肿瘤的7%～10%[1]。糖代谢紊乱与乳腺癌的病理进展密切相关，为有效控制乳腺癌化疗伴糖代谢紊乱患者血糖水平，该院自2012年2月以来对AC-T常规化疗方案进行改进，加用二甲双胍，现将研究结果报道如下，现报道如下。 　　1 资料