免疫性不孕不育.pptxVIP

http://www.drsonubalhara.in/infertility-doctor-sonu-balhara/Immunity infertility免疫性不孕不育IMMUNOLOGYCLASSIFICATION2ALLOIMMUNITY同种免疫AUTOIMMUNITY1LOCAL IMMUNITY3自身免疫局部免疫免疫性习惯流产01recurrent miscarriage Immunological acceptanceIMMUNOLOGYProblems with Embryo SignalingOnce conception has taken place the developing embryo must signal the mother’s immune cells to recognize it as “self” rather than a foreign invader. The embryo does this by secreting HLA G antigen to signal the mother’s immune cells to allow it to grow and stay. In this case HLA G antigen improperly functions and the mother’s immune cells attack the embryo, eventually resulting in miscarriage. This is considered a HLA G gene mutation.2% of women of reproductive age experience habitual miscarriage.?Problems with Embryo Signaling?Problems with the Mother’s Immune Response to the Embryo?Thrombophilia: Blood Clotting Issue/immune-infertility.htmlProblems with Embryo Signaling2% of women of reproductive age experience habitual miscarriage.?Problems with Embryo Signaling?Problems with the Mother’s Immune Response to the Embryo?Thrombophilia: Blood Clotting Issue/articles/cmi201453/figures/1Problems with the Mother’s Immune Response to the EmbryoThis is when the mother’s immune cells do not respond to the healthy signal of HLA G antigen release. Again, the mother’s immune cells attack the embryo. When an embryo is attacked it is not destroyed, but causes inactivation of the DNA in the embryo so that these cells stop dividing and replicating. The embryo fails to grow and dies. 2% of women of reproductive age experience habitual miscarriage.?Problems with Embryo Signaling?Problems with the Mother’s Immune Response to the Embryo?Thrombophilia: Blood Clotting Issue/immune-infertility.htmlThrombophilia: Blood Clotting IssueThis happens after the mother’s body recognizes the baby as part of herself and the embryo has implanted. The vessels in the placenta take blood and nutrients to the fetus. In the case of a blood clotti