中青年隐源性缺血性脑卒中与卵圆孔未闭临床研究.docVIP

中青年隐源性缺血性脑卒中与卵圆孔未闭的临床研究 　　【摘要】 目的：探讨中青年隐源性缺血性脑卒中（cryptogenic ischemic stroke，CS）与卵圆孔未闭（patent foramen ovale，PFO）的关系。方法：选取2013年1月-2016年1月本院收治的中青年不明原因急性缺血性脑卒中患者128例作为研究组，同时选取与研究组年龄、性别等基本相匹配的健康体检者108例为对照组。所有脑卒中患者行右心声学造影和经食管超声心动图（transesophageal echocardiography，TEE）?\断PFO，并比较两种方法的检出率。对两组患者的高血压、糖尿病、冠心病、颈部斑块等高危因素进行统计分析，比较两组间PFO的检出率及高危因素的差异。结果：研究组PFO检出率为48.4%（62/128），明显高于对照组的13.9%（15/108），差异有统计学意义（P0.05）。两种方法联合检出率97.4%（75/77）。两组其他脑卒中发病的危险因素比较，差异均无统计学意义（P0.05）。结论：PFO与中青年CS患者有密切关系，在临床中，对于不明原因的隐源性脑卒中患者，应想到PFO存在的可能性，右心声学造影及TEE都是检查PFO的重要检查方法，两者联合运用可以提高检出率。 　　【关键词】 右心声学造影； 食管超声心动图； 隐源性缺血性脑卒中； 卵圆孔未闭 　　Clinical Study of Young Patients with Cryptogenic Ischemic Stroke and Patent Foramen Ovale/WANG Hao，SONG Yan，DENG Ya-qin，et al.//Medical Innovation of China，2017，14（30）：008-011 　　【Abstract】 Objective：To investigate the relationship between cryptogenic ischemic stroke（CS） and patent foramen ovale （PFO） in young and middle-aged patients.Method：From January 2013 to January 2016，in our hospital 128 unexplained young and middle-aged patients with acute ischemic stroke were selected as study group，at the same time，selection and study group such as age and gender matched healthy subjects served as the control group of 108 cases.All stroke patients right heart contrast echocardiography and transesophageal echocardiography （TEE） PFO diagnosis，the detection rate and the comparison of the two methods.The hypertension，diabetes，coronary heart disease，neck plaque and other high-risk factors of the two groups were statistically analyzed，compared between the two groups of PFO detection rate and high-risk factors.Result：The detection rate of PFO in the study group was 48.4% （62/128），significantly higher than 13.9%（15/108） in the control group，the difference was statistically significant （P0.05）.The combined detection rate of two methods was 97.4% （75/77）.There was no significant difference between the two groups in the risk factors of other stroke（P0.05）.Conclusion：PFO has a close relationship