他克莫司治疗膜性肾病效果及对患者T淋巴细胞亚群影响.docVIP

他克莫司治疗膜性肾病的效果及对患者T淋巴细胞亚群的影响 　　[摘要]目的 探讨他克莫司治疗膜性肾病的效果及对患者T淋巴细胞亚群的影响。方法 选取2015年10月～2017年7月我院收治的82例膜性肾病患者作为研究对象，按照随机数字表法将其分为两组，每组各41例。所有患者常规应用泼尼松，除此以外对照组患者采用来氟米特治疗，观察组患者则联合他克莫司治疗，6个月为1个疗程。比较两组患者治疗前后的24 h尿蛋白、血肌酐、CD3+、CD4+/CD8+指标水平及临床治疗总有效率。结果 治疗后，观察组患者的24 h尿蛋白、血肌酐水平低于对照组，差异有统计学意义（P0.05）。观察组患者的CD3+及CD4+/CD8+低于对照组，差异有统计学意义（P0.05）。观察组患者的治疗总有效率（80.49%）高于对照组（58.54%），差异有统计学意义（P0.05）。结论 他克莫司联合泼尼松治疗膜性肾病效果显著，可更好地改善患者的肾功能水平，调节免疫功能，安全可靠，值得推广。 　　[关键词]他克莫司；膜性肾病；T淋巴细胞亚群；肾功能 　　[中图分类号] R979.5 [文献标识码] A [文章编号] 1674-4721（2018）1（c）-0111-03 　　Effect of Tacrolimus in the treatment of membranous nephropathy and its effect on patients with T lymphocyte subsets 　　MIAO Sheng-ju CHEN Li-sa HAN Fang 　　Department of Nephrology，Hubei Hospital of Integrated Traditional Chinese and Western Medicine，Hubei Province，Wuhan 430015，China 　　[Abstract]Objective To investigate the effect of Tacrolimus in the treatment of membranous nephropathy and its effect on patients with T lymphocyte subsets.Methods From October 2015 to July 2017，82 patients with membranous nephropathy treated in our hospital were selected as subjects of the study and were divided into two groups according to the random number table method，41 cases in each group.Prednisone was used in all patients.In addition to the control group，the patients were treated with Leflunomide，and the patients in the observation group were treated with Tacrolimus，6 months was one course of treatment.The levels of the 24 h urinary protein，serum creatinine，CD3+，CD4+/CD8+ before and after treatment and the total effective of clinical treatment between the two groups were compared.Results After treatment，the 24 h urinary protein and serum creatinine levels in the observation group were lower than those in the control group，and the differences were statistically significant （P0.05）.The CD3+ and CD4+/CD8+ in the observation group were lower than those in the control group，and the differences were statistically significant （P0.05）.The total effective treatmen