代谢综合征病位证素与胰岛素抵抗过氧化物酶体增殖物激活受体和体重指数相关性研究.docVIP

代谢综合征病位证素与胰岛素抵抗、过氧化物酶体增殖物激活受体和体重指数的相关性研究 　　摘 要 目的：研究代谢综合征的病位证素与胰岛素抵抗（IR）、过氧化物酶体增殖物激活受体（PPAR）-γ及体重指数（BMI）的相关性。方法：通过问卷调查纳入曹杨社区代谢综合征患者206例，检测IR、PPAR-γ和BMI，分析病位证素与这些指标的相关性。结果：代谢综合征病位证素为肾、肝、脾，与IR、PPAR-γ和BMI相关。结论：IR、PPAR和BMI可为临床代谢综合征中医辨证的指标。 　　关键词 代谢综合征 病位证素 胰岛素抵抗 过氧化物酶体增殖物激活受体 体重指数 　　中图分类号：R589 文献标识码：A 文章编号：1006-1533（2015）10-0007-03 　　The study on relationship between metablic syndrome of traditional Chinese medicine and the factors of insulin resistance， PPAR-γ and BMI 　　ZHOU Yixin1， HAN Zhenxiang1， QI Lili 2， CAI Weiqing3， ZHOU Yuhao1， SONG Hongpu4， HUANG JingYi3， ZHANG Huiyan3 　　（1.Shanghai Seventh Peoples Hospital， Shanghai 200137， China； 2.Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine， Shanghai 200437， China； 3. Caoyang Community Health Service Center of Pudou District， Shanghai 200062， China； 4.Shanghai University of Chinese Medicine， Shanghai 200030， China） 　　ABSTRACT Objective： To study the relationship between metablic syndrome of traditional Chinese medicine （TCM） and factors of insulin resistance， peroxisomeproliferator activated receptor（PPAR）-γand body mass index （BMI）. Methods： Two hundres and six patients with metabolic syndrome in the Caoyang Community were collected using questionnaire. The level of the PPAR-γwas examined，the insulin resistance and the BMI of the patients were measured. The relationship between metabolic syndrome of TCM and three factors was analyzed. Results： The metabolic syndrome of TCM inferred kidney， liver and spleen，and was related to insulin resistance， PPAR-γ and BMI. Conclusion： The three factors can be used as the objective indexes for clinical metabolic syndrome of TCM. 　　KEY WORDS metabolic syndrome； metabolic syndrome of traditional Chinese medicine； insulin resistance； peroxisomeproliferator activated receptor -γ； body mass index 　　代谢综合征是以糖和脂肪代谢紊乱为核心的一组症候群，是心血管疾病和多种代谢危险因素在个体内聚集的状态，其很多征候、相关疾病可见于“消渴”、“肥胖”、“眩晕”、“胸痹”等病。本研究在既往研