依据药敏结果调整抗生素供给与抗生素强度使用临床研究.docVIP

依据药敏结果调整抗生素供给与抗生素强度使用的临床研究 　　【摘要】 目的 依据药敏结果调整医院抗生素供给， 研究促进临床规范使用抗生素并减少抗生素使用强度的可行性。方法 回顾性分析依据药敏结果调整前100例住院患者及依据药敏结果调整后100例住院患者的抗菌药物使用情况， 比较患者调整前后的抗菌药物限定日剂量（DDD）、用药频度（DDDs）、抗菌药物使用强度（AUD）、住院时间及基药使用率。结果 调整前的AUD及DDDs明显高于调整后， 差异有统计学意义（P0.05）；调整后患者住院时间较调整前显著缩短， 差异具有统计学意义（P0.05）；调整前的基药使用率为38%， 低于调整后的65%， 差异具有统计学意义（P0.05）。结论 依据药敏结果调节抗生素供应， 能够规范并显著降低临床抗生素使用强度及治疗时间， 值得推广。 　　【关键词】 药敏实验；抗菌药物使用强度；抗菌药物使用频度 　　DOI：10.14163/j.cnki.11-5547/r.2017.02.058 　　Clinical research of antibiotics supply and antibiotics use density adjustment in accordance with drug sensitivity test outcome OU Da-gang， ZHANG Dong-wu， WANG Fu-hai. Foshan City Gaoming District People’s Hospital， Foshan 528500， China 　　【Abstract】 Objective To adjust antibiotics supply in accordance with drug sensitivity test outcome， and to research feasibility of standardized clinical use of antibiotics and low antibiotics use density. Methods A retrospective analysis was made on antibiotics use in 100 hospitalized patients before adjustment by drug sensitivity test outcome and 100 hospitalized patients after adjustment by drug sensitivity test outcome. Comparison was made on antibiotics defined daily dose （DDD）， defined daily doses （DDDs）， antibiotics use density （AUD）， hospital stay time and essential medicine usage rate in patients before and after adjustment. Results AUD and DDDs before adjustment were obviously higher than those after adjustment， and their difference had statistical significance （P0.05）. After adjustment， patients had much shorter hospital stay time than before adjustment， and the difference had statistical significance （P0.05）. Essential medicine usage rate was lower as 38% before adjustment than 65% after adjustment， and the difference had statistical significance （P0.05）. Conclusion Antibiotics supply adjustment in accordance with drug sensitivity test outcome can standardize and remarkably reduce antibiotics use density and treatment duration， and this method is worth promoting. 　　【Key words】 Drug