放疗同步化疗对宫颈癌患者临床疗效的初步观察.docVIP

放疗同步化疗对宫颈癌患者临床疗效的初步观察 　　【摘要】目的：探讨放疗同步化疗局部晚期宫颈癌患者的治疗效果。方法：对2008年1月至2009年月3月入我院肿瘤中心治疗的86例局部晚期宫颈癌患者按1∶1比例分为两组，每组各43例，对照组给予50～54 Gy盆腔照射，观察组患者在对照组基础上给予吉西他滨+顺铂（GP）进行化疗，化疗周期为21d，共化疗4～6个疗程，观察两组患者的治疗效果及毒副反应。结果：观察组患者完全缓解率明显高于对照组（χ2=4305，P001），差异具有统计学意义；观察组2、3年内复发率明显低于对照组（P005）。结论：放疗同步化疗治疗晚期宫颈癌近期疗效确切，可明显改善患者的预后，提高患者生活质量。 　　【关键词】放疗；吉西他滨；顺铂；宫颈癌；疗效；毒副反应 　　Efficacy of concurrent chemotherapy and radiotherapy in patients with cervical cancerMIREGULI.AkeMuJiang1， SU LAIYA.HuSaiyin2. 1. Department of Obstetrics and Gynecology， MI dong Branch of People’s Hospital of Xinjiang Uygur Autonomous Region，Urumqi 830021， China； 2. Department of Gynecology， Xinjiang Uygur Autonomous Region People’s Hospital， Urumqi 830001， China 　　【Abstract】Objectives： To investigate the effect of radiation therapy with concurrent chemotherapy for locally advanced cervical cancer patients. Methods： January 2008 to March 2009 years into the hospital cancer centers treat 86 patients with locally advanced cervical cancer patients with a 1： 1 ratio into two groups， 43 cases in each group， the control group received 50 ～ 54 Gy pelvic irradiation， the observation group were treated with gemcitabine in the control group on the basis of gemcitabine + cisplatin （GP） chemotherapy， chemotherapy cycle is 21 days， a total of four to six courses of chemotherapy， the treatment effect was observed in both groups of patients， and toxicity. Results： The complete remission rate was significantly higher （χ2 = 4.305， P001）， a statistically significant difference； observation group 2， 3 year recurrence rate was significantly lower than the control group （P005）. Conclusion： Radiotherapy and chemotherapy in patients with advanced cancer recently efficacy， can significantly improve the prognosis of patients， improve the quality of life of patients. 　　【Key words】Radiotherapy； Gemcitabine； Cisplatin； Cervical cancer； Efficacy； Toxicities 　　【中图分类号】R71174【文献标志码】A 　　宫颈癌是妇科最常见的恶性肿瘤之一，据最新统计数据显示，其发病率不断上升，且发病逐渐趋于年青化，目前，仅次于乳腺癌，在妇科肿瘤中位居第