改良电抽搐治疗难治性精神分裂症阴性症状疗效研究.docVIP

改良电抽搐治疗难治性精神分裂症阴性症状疗效研究 　　[摘要] 目的 探讨不同治疗次数的改良电抽搐（MECT）治疗难治性精神分裂症阴性症状疗效及对记忆功能的影响。方法 80例难治性精神分裂症患者随机分为三组，在对照组给予氯氮平治疗的同时，研究组分别联合8次（研究1组）、12次（研究2组）MECT治疗。采用阳性与阴性症状量表（PANSS）及韦氏成人记忆量表（WMS）评定疗效和记忆功能。 结果 治疗8周末，研究1、2组的显效率和有效率均高于对照组（P0.05）。除治疗4周末研究1组和对照组的阴性症状量表分与治疗前比较以及此两组间比较差异均无统计学意义（P0.05）之外，三组的各量表分及PANSS总分均低于治疗前、两研究组的各量表分及PANSS总分均低于对照组，差异均有统计学意义（P0.05）。 结论 氯氮平联合12次MECT很有效地改善难治性精神分裂症的阴性症状，且对记忆功能无不良影响。 　　[关键词] 改良电抽搐治疗；难治性精神分裂症；阴性症状；氯氮平 　　[中图分类号] R749.3 [文献标识码] B [文章编号] 1673-9701（2015）34-0089-03 　　Modified electroconvulsive therapy in the treatment of refractory schizophrenia’ negative symptoms 　　YU Shaojun LIU Xiaofang LIU Yanyu GONG Shaogong 　　Department of Psychiatry， Kangning Hospital of Jiangxi Province， Zhangshu 331211， China 　　[Abstract] Objective To explore efficacy and safety on memory of different treatment times MECT（modified electroconvulsive therapy） in the treatment of refractory schizophrenia’negative symptoms. Methods A total of 80 patients with refractory schizophrenia（TRS） were randomly assigned to receive clozapine combined with 8 times MECT （study 1 group） or with 12 times MECT （study 2 group） and clozapine treatment （control group） for 8 weeks. Positive and negative syndromes scale（PANSS） was used to evaluate efficacy before treatment and at the ends of the 4th and 8th week treatment. The wechsler memory scale（WMS） was used to evaluate the memory level before and 8 weeks after the treatment. Results After 8 week treatment， the explicit efficiency of study 2 group was significantly higher than study 1 group and control group（P0.05）. The PANSS-T（total score）， PANSS-P （positive scale） and PANSS-G（general psychopathology scale） were significantly lower in two study groups than control group after 4 and 8 week treatment（P0.05）. Conclusion Clozapine combined with 12 times MECT is effective and safty on memory in the treatment of refractory schizophrenia’ negative symptoms. 　　[Key words] Modified electroconvulsive therapy； Refractory schizophrenia； Nega