利培酮与齐拉西酮治疗有精神病性症状抑郁症疗效评价与比较.docVIP

利培酮与齐拉西酮治疗有精神病性症状抑郁症疗效评价与比较 　　【摘要】 目的 探?利培酮与齐拉西酮治疗有精神病性症状抑郁症的临床疗效， 对两种药物的安全性进行比较。方法 80例有精神病性症状的抑郁症患者， 随机分为利培酮组和齐拉西酮组， 各40例。利培酮组患者给予利培酮治疗， 齐拉西酮组采用齐拉西酮治疗。观察并记录两组患者治疗前后的阳性和阴性症状量表（PANSS）评分及用药过程中的不良反应。结果 利培酮组治疗总有效率为87.50%， 齐拉西酮组治疗总有效率为90.00%， 两组治疗效果比较差异无统计学意义（P0.05）；治疗前， 两组患者PANSS评分总分和各因子分比较差异无统计学意义（P0.05）。两组患者经过2周治疗后， PANSS评分总分和各因子分均有显著降低， 治疗4、8周各因子分及总分相较于治疗前有明显降低（P0.05）。利培酮组出现泌乳、体重增加、椎体外系反应、月经改变等不良反应明显高于齐拉西酮组， 差异具有统计学意义（P0.05）。结论 利培酮和齐拉西酮对治疗有精神病性症状的抑郁症患者均有很好的疗效， 但齐拉西酮产生的副作用比较少， 进一步增加患者药物治疗的依从性， 更加利于抑郁症状的缓解， 值得临床推广使用。 　　【关键词】 利培酮；齐拉西酮；精神病性症状；抑郁症 　　DOI：10.14163/j.cnki.11-5547/r.2017.09.043 　　Evaluation and comparison of curative effects by risperidone and ziprasidone in the treatment of depression with psychotic symptom LI Hai-hong. Liaoning Fuxin City Fourth People’s Hospital， Fuxin 123000， China 　　【Abstract】 Objective To investigate clinical effects by risperidone and ziprasidone in the treatment of depression with psychotic symptom， and to compare safety by the two drugs. Methods A total of 80 depression with psychotic symptom patients were randomly divided into risperidone group and ziprasidone group， with 40 cases in each group. The risperidone group received risperidone for treatment， and the ziprasidone group received ziprasidone for treatment. Observation and records were made on positive and negative syndrome scale （PANSS） scores and adverse reactions during medication between the two groups before and after treatment. Results The risperidone group had total effective rate in treatment as 87.50%， and the ziprasidone group had total effective rate in treatment as 90.00%. There was no statistically significant difference of curative effect between the two groups （P0.05）. Before treatment， there was no statistically significant difference of total PANSS score and factor scores between the two groups （P0.05）. After 2 weeks of treatment， both groups had obviously decreasing total PANSS score and factor scores. In 4 and 8 weeks of treatment， both groups had much