南海农村地区血尿酸水平及干预治疗对冠心病影响前瞻性研究.docVIP

南海农村地区血尿酸水平及干预治疗对冠心病影响前瞻性研究 　　[摘要] 目的 观察南海区农村人群的血尿酸水平，前瞻性随访观察伴不同尿酸浓度及不同治疗方法对冠心病的影响。方法 选择2012年8月～2015年3月在本院就诊及健康体检的南海区农村人口732例，合并冠心病226例。患者随机分为别嘌呤醇干预组及对照组，测定血尿酸水平，并测量baPWV（肱-踝脉搏波速度）、ABI（踝臂指数）。观察不同尿酸水平及干预治疗对冠心病的发生、发展情况、baPWV、ABI的影响。 结果 两组732例高尿酸血症患者，基线三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）比较差异无统计学意义。经别嘌呤醇干预治疗3个月后，干预组血尿酸明显低于对照组（P0.05）。 结论 在南海农村地区高尿酸血症人群中，别嘌呤醇降尿酸治疗可改善动脉僵硬度，延缓合并冠心病患者动脉硬化过程。 　　[关键词] 高尿酸血症；肱-踝脉搏波速度；踝臂指数；别嘌呤醇 　　[中图分类号] R541.4 [文献标识码] A [文章编号] 1673-9701（2015）23-0008-04 　　Prospective study of influence of blood uric acid and intervention treatment on coronary heart disease in rural area of Nanhai 　　MAO Lin 　　Department of Internal Medicine， Foshan City Fifth Peoples Hospital in Guangdong Province， Foshan 528211， China 　　[Abstract] Objective To observe the blood uric acid levels of the rural population in Nanhai district and observe prospectively the influences of different concentrations of uric acid and different treatment methods on the coronary heart disease. Methods A total of 732 rural people in Nanhai district who were treated or received health examination in our hospital from August 2012 to March 2015， including 226 people complicated by coronary heart disease， were selected consecutively. They were divided into allopurinol intervention group and control group， the blood uric acid levels were measured and the baPWV（brachial-ankle pulse wave velocity） and ABI（ankle brachial index） were detected. The influences of different uric acid levels and intervention treatment on the occurrence and development of coronary heart disease， baPWV and ABI were observed. Results The two groups of patients with hyperuricemia were not significantly different in baseline triglyceride（TG）， total cholesterol（TC）， high density lipoprotein cholesterol（HDL-C） and low-density lipoprotein cholesterol（LDL-C）. After 3 months of allopurinol intervention treatment， the intervention group was significantly lower than the control group in the blood uric acid（P0.05