厄贝沙坦对老年高血压左心室肥厚及舒张功能影响.docVIP

厄贝沙坦对老年高血压左心室肥厚及舒张功能影响 　　[摘要] 目的：观察厄贝沙坦对老年高血压左室肥厚（LVH）及舒张功能的影响。方法：78例患者口服厄贝沙坦150 mg，每天1次，治疗32周，分别测量血压以及彩色多普勒超声检测左室舒张末内径（LVDd）、左室舒张期室间隔厚度（IVST）、左室后壁厚度（LVPWT）、左室心肌重量指数（LVMI）、左室射血分数（LVEF）、二尖瓣口舒张早、晚期血流峰值速度E/A比值。结果：治疗后血压（SBP/DBP）、LVDd、IVST、LVPWT、LVMI均明显下降（P0.05），LVEF、E/A均明显上升（P0.05）。结论：厄贝沙坦不仅能有效降低老年人高血压和逆转其左心室肥厚，而且能明显改善其左心舒张功能。[关键词] 高血压；左心室肥厚；厄贝沙坦 　　[中图分类号] R541.3 [文献标识码]A[文章编号]1673-7210（2011）07（c）-083-02 　　 　　Effects of Irbesartan on left ventricular hypertrophy and diastolic function in elderly patients with hypertension 　　LI Xinrong, CHEN Xiehui, ZENG Muyun, ZHANG Yan, WU Bo 　　Department of Geriatric, the Second People′s Hospital of Futian District in Shenzhen City, Guangdong Province, Shenzhen 518049, China 　　[Abstract] Objective: To observe the effect of Irbesartan on left ventricular hypertrophy and left ventricular diastolic function in elderly patients. Methods: 78 cases of elderly patients with left ventricular hypertrophy were given Irbesartan 150 mg once daily for 32 weeks. left ventricular diastolic diameter (LVDd), left ventricalar septal thick(IVST), left ventricular posterior wall thick (LVPWT), left ventricular ejection fraction (LVEF), left ventricular mass index(LVMI) , the ratio of peak flow velocity in early diastolic to that at atrial contraction (E/A) were measured by Doppler echocardiography. Results: After 12 months treatment, blood pressure (SBP/DBP), LVDd, IVST, LVPWT and LVMI decreased significantly (P0.05), LVEF, E/A increased significantly (P＜0.05). Conclusion: Irbesartan not only can decrease the hypertension and remodel the hypertrophied ventricle, but also improve left ventricular diastolic function. 　　[Key words]Hypertension; Left ventricular hypertrophy; Irbesartan 　　 　　高血压（HE）是一种慢性病，也是一种不断进展的疾病，高血压已成为一个重要的公共卫生问题[1]，目前我国老年高血压患者已达8 346万，约每2名老年人中就有1名患有高血压，而且，老年高血压患患者数呈持续增加的趋势[2]。老年高血压并发左室肥厚（LVH）的发生率在50%左右，它可降低冠状动脉储备，并是心肌梗死、心力衰竭、心律失常和猝死的一个重要的独立危险因素，为高血压治疗的强指征[3]。左室肥厚的逆转也是治疗高血压有效的客观指标[1]。本文旨在观察厄贝沙坦对老年高血压病的降压疗效以及对LVH逆转作用，现报道如下：