单阻断法气道阻力测定在婴幼儿喘息性疾病中临床意义.docVIP

单阻断法气道阻力测定在婴幼儿喘息性疾病中临床意义 　　[摘要] 目的:探讨单阻断法气道阻力测定在婴幼儿喘息性疾病中的临床应用价值。方法:对毛细支气管炎、婴幼儿哮喘各55例及对照组35例在吸入特布他林前后进行气道阻力测定。结果:用药前毛细支气管炎组、哮喘组气道阻力值与对照组比较,差异有高度统计学意义(P0.05);毛细支气管炎组、哮喘组用药前后气道阻力值比较,差异有高度统计学意义(P0.01)。结论:单阻断法气道阻力测定可反映婴幼儿喘息性疾病气道阻塞的状况,给临床诊断治疗提供有力的客观依据。 　　[关键词] 喘息性疾病;气道阻力;单阻断法 　　[中图分类号] R725.6[文献标识码]A [文章编号]1673-7210(2010)06(c)-021-02 　　 　　The clinical significance of airway resistance measurement in asthmic infants using interrupter technique 　　ZHANG Shuxia, YAN Yong, LI Li 　　(Department of Pediatrics, Weifang Maternal and Child Hospital, Shandong Province, Weifang 261011, China) 　　[Abstract] Objective: To investigate the clinical value of airway resistance measurement using interrupter technique in infants with asthmic diseases. Methods: Airway resistance was measured before and after terbutaline inhalation in 55 infants with bronchiolitis or asthma and 35 healthy infants. Results: The value of airway resistance was higher in infants with either bronchiolitis or asthma than control subjects before inhalation, but did not differ significantly after inhalation from control subjects. The value of airway resistance on the infants of bronchiolitis and asthma differ significantly before and after inhalation. Conclusion: Measurements of airway resistance using the interrupter technique can reflect the conditions of airway obstruction and are valuable for clinical diagnosis in asthmic infants. 　　[Key words] Asthmic disease; Airway resistance; Interrupter technique 　　 　　小儿喘息性疾病如毛细支气管炎、支气管哮喘在儿童中相当普遍。对≥5岁的喘息性疾病患儿可用简易峰流速仪来监测肺功能,但5岁的患儿大多不能合作,迫切需要简便、快捷的方法,对病情和疗效作出客观评价。2007年1月～2008年1月,笔者应用单阻断法对毛细支气管炎、婴幼儿哮喘患儿各55例进行气道阻力测定,现将结果报道如下: 　　1 对象与方法 　　1.1 对象 　　2007年1月～2008年1月在我院儿科住院的患儿:①毛细支气管炎组55例,符合《诸福棠实用儿科学》[1]中关于毛气支气管炎的诊断标准。其中,男37例,女18例;年龄10个月～3岁,平均1岁5个月;病程2～5 d。②哮喘组55例,符合儿童支气管哮喘防治常规诊断标准[2]。其中,男36例,女19例;年龄11个月～3岁,平均1岁8个月;病程2～5 d。两组患儿入院前均未应用激素及支气管扩张剂治疗。③对照组35例,来自我院儿童保健科健康查体的儿童。其中,男23例,女12例;年龄10个月～3岁,平均1岁10个月;无呼吸和心血管系统疾病,无影响肺功能的先天性疾病。三组性别、年龄差异无统计学意义(P0.05),具有可比性。 　　1.2 方法 　　应用