基于互信息失眠用药关联性分析.docVIP

基于互信息失眠用药关联性分析 　　[摘要]基于中医传承辅助系统软件，分析郭蓉娟教授治疗失眠的用药经验。收集郭蓉娟教授治疗失眠的中药方剂，采用关联规则apriori算法、改进的互信息算法、复杂系统熵聚类等无监督数据挖掘方法，确定处方中各种药物的使用频次及药物之间的关联规则，分析郭蓉娟教授治疗失眠的用药经验。对筛选出的3 084首处方进行分析，确定处方中药物的使用频次，药物之问的关联规则，挖掘出41个核心组合和7首新处方。结论符合郭教授对失眠病因病机的认识：以肝郁化火为核心病机，肝郁脾虚、久病及肾的特点，中医传承辅助系统对于挖掘名中医临床经验具有重要实用价值。 　　[关键词]失眠症；关联规则；互信息；聚类算法 　　[Abstract]This paper aims to analyze Professor Guo Rongjuan′s medication experience on insomnia therapy based on the Traditional Chinese Medicine （TCM） Inheritance Support Plat First， TCM formulae prescribed by Professor Guo for insomnia therapy were collected from the TCM Inheritance Support Plat Next， unsupervised data mining algorithms， including apriori， modified mutualinformation， and entropy clustering of complex system were applied to obtain the frequencies for different herbs and identify the association rules among the herbs Accordingly， we can gain new insights into Professor Guo′s medication experience on insomnia therapyBased on analysis of 3 084 formulae， we determined the frequencies for herbs in the formulae and identified the association rules among these herbs At last， 41 core combinations and 7 new formulae were obtainedThe identified medication experience conform with Professor Guo′s views on the etiology and pathogenesis of insomnia： “pathogenic fire derived from stagnation of liverQI （Gan Yu Hua Huo）” is the core pathogenesis of insomnia； “liver stagnation and spleen deficiency” and “chronic illness transferred to kidney” are the main features for insomnia The TCM Inheritance Support Plat is of great practical value for mining clinical experience of famous TCM doctors 　　[Key words]insomnia； association rule； mutual information； clustering algorithm 　　失眠（sleeplessness）是指无法进入睡眠状态或者无法长时间保持睡眠状态，从而导致人体睡眠不足，又称为入睡和维持睡眠障碍（DIMS）[1]。表现为入睡困难，睡眠断断续续不连贯，或者过早地醒来，醒后不能再继续睡，有睡眠不足，全身乏力，倦怠的感觉，失眠多因健康情况不佳，身体疼痛、感觉不适，人体生理节奏被打乱，睡眠环境影响等因素引起，可以根据不同的原因采取对应的措施。 　　中医称失眠为“不寐”（见《难经?第四十六难》），“夜不瞑”（见《灵枢?营卫生会》）、“目不瞑”（见《灵枢?大惑论》）[2]。 　　失眠是医疗临床常见的病症，虽然不属于危重疾病，但是由于失眠妨碍人们的正