多西他赛与顺铂单药化疗同期放疗治疗非手术食管癌对照研究.docVIP

多西他赛与顺铂单药化疗同期放疗治疗非手术食管癌对照研究 　　[摘要] 目的 比?^多西他赛与顺铂单药化疗同期放疗治疗非手术食管癌的疗效及安全性。方法 方便收集2011年1月―2013年2月在该院住院治疗的失去手术治疗机会的原发性食管癌患者70例。根据治疗方法分为顺铂组35例和多西他赛组35例。所有患者均接受相同放疗方案，多西他赛组在放疗同期给予多西他赛治疗；顺铂组患者在放疗同期给予顺铂治疗。比较两组的生存期、近期疗效及不良反应发生情况。结果 顺铂组生存时间、1年生存率分别为（20.2±3.2）个月、60.0%，多西他赛组分别为（21.0±4.5）个月、57.1%，两组比较差异无统计学意义（P0.05），多西他赛组的近期有效率为100.0%，明显高于顺铂组的82.9%（P0.05）。结论 多西他赛联合同期放疗对非手术食管癌的有效率较高，毒副作用较轻，值得临床借鉴推广。 　　[关键词] 多西他赛；顺铂；非手术食管癌 　　[中图分类号] R735.1 [文献标识码] A [文章编号] 1674-0742（2017）01（c）-0129-03 　　Comparative Research on Concurrent Radiotherapy and Chemotherapy of Docetaxel and Cisplatin Single-agent in Treatment for Non-operative Esophageal Cancer 　　ZHANG Tie-yi， WANG Yan-ni， ZHANG Hui 　　Department of Pharmacy， Rongcheng People’s Hospital， Rongcheng， Shandong Province， 264300 China 　　[Abstract] Objective To compare the curative effect and safety of concurrent radiotherapy and chemotherapy of docetaxel and cisplatin single-agent in treatment for non-operative esophageal cancer. Methods 70 cases of patients with primary esophageal cancer losing the operative treatment chance in our hospital from January 2011 to February 2013 were convenient collected and divided into two groups with 35 cases in each， and all patients received the same radiotherapy plan， the docetaxel group were treated with cisplatin at the radiotherapy period， while the Cisplatin group were treated with cisplatin at the radiotherapy period， and the survival period， short-term curative effect and occurrence of side effects were compared between the two groups. Results The differences in the survival time and 1-year survival rate between the Cisplatin group and the docetaxel group had statistical significance by comparison[（20.2±3.2）months， 60.0% vs （21.0±4.5）months， 57.1%]，（P0.05）， and the short-term effective rate in the docetaxel group was obviously higher than that in the cisplatin group， （100.0% vs 82.9%），（P0.05）. Conclusion The effective rate of docetaxel combined with the radiotherapy at the same period is highe