基于肿瘤标志物mRNA表达检测指导性化疗治疗对NSCLC患者近远期疗效影响.docVIP

基于肿瘤标志物mRNA表达检测指导性化疗治疗对NSCLC患者近远期疗效影响 　　【摘要】 目的：探?基于肿瘤标志物mRNA表达检测的指导性化疗治疗对非小细胞肺癌（NSCLC）患者近远期疗效的影响。方法：选取2012年1月-2014年12月笔者所在医院确诊治疗的NSCLC患者100例，依据随机数字表法随机分为指导组和常规组，每组50例，常规组给予诺维本联合顺铂方案化疗治疗，指导组给予基于肿瘤标志物mRNA表达检测的指导性化疗（采用液相芯片技术检测肿瘤组织多种标志物mRNA后并依此选择化疗方案）治疗，随访2年，统计分析所有患者治疗效果、不良反应，治疗后0.5、1、2年的累积生存情况。结果：指导组治疗有效率明显高于常规组，差异有统计学意义（P0.05）；指导组不良反应发生率明显低于常规组，化疗疗程明显高于常规组，差异均有统计学意义（P0.05）；指导组治疗后0.5、1、2年累积生存率均明显高于常规组，差异均有统计学意义（P0.05）。结论：基于肿瘤标志物mRNA表达检测的指导性化疗治疗可有效提高NSCLC患者的治疗疗效，且可有效减少药物毒副作用而提高耐受性，有利于改善生存预后水平，值得临床作进一步推广。 　　【关键词】 肿瘤标志物； mRNA表达； 指导性化疗； 非小细胞肺癌； 近远期疗效 　　Near and Forward Future Curative Effect of Based on mRNA Expression of Tumor Markers Detection Guidance Chemotherapy Treatment in Patients with NSCLC/XIE Feng，CHEN Chang-nan，LIN Yun-xiao.//Medical Innovation of China，2017，14（11）：024-027 　　【Abstract】 Objective：To discuss the near and forward future curative effect of based on mRNA expression of tumor markers detection guidance chemotherapy treatment in patients with non-small cell lung cancer（NSCLC）.Method：A total of 100 patients with NSCLC were selected from January 2012 to December 2014 in our Hospitals.According to the random distribution，all patients were divided into steering group and conventional group， 　　50 cases in each group.Conventional group was given novy this combined cisplatin chemotherapy，steering group was given based on mRNA expression of tumor markers detection guidance chemotherapy（used liquid chip technology to detect a variety of tumor markers mRNA and chemotherapy regimens in this choice） treatment，followed up for 2 years，statistical analyzed all of the patients after treatment efficacy，adverse reactions，the accumulation of 0.5，1， 2 years’s survival condition.Result：The therapeutic response rate of steering group was significantly higher than that of conventional group，there was statistically significant difference（P 　　【Key words】 Tumor markers detection； mRNA expression； Chemotherapy guidance； Non-small cell lung cancer； Near and forward future