外周血T淋巴细胞亚群及免疫球蛋白水平对手足口病患儿免疫功能联合诊断价值研究.docVIP

外周血T淋巴细胞亚群及免疫球蛋白水平对手足口病患儿免疫功能联合诊断价值研究 　　【摘要】 目的 探讨联合检测外周血T淋巴细胞亚群及免疫球蛋白水平对诊断手足口病患儿免疫功能的价值。方法 200例手足口病患儿作为手足口病组， 100例健康体检小儿作为健康组， 检测两组小儿CD3+、CD4+、CD8+、CD4+/CD8+及免疫球蛋白（Ig）A、IgM、IgG水平。结果 健康组CD3+、CD4+、CD8+水平[（65.83±7.24）%、（41.32±4.74）%、（25.27±3.13）%]均高于手足口病组[（52.72±4.83）%、（32.45±3.21）%、（20.13±2.35）%]， 差异均具有统计学意义（P0.05）。健康组IgA、IgG水平[（1.16±0.25）、（9.21±1.63）g/L]高于手足口病组[（0.58±0.13）、（7.87±1.21）g/L]， 差异均具有统计学意义（P0.05）。结论 联合检测外周血T淋巴细胞亚群及免疫球蛋白水平诊断手足口病患儿免疫功能价值较高。 　　【关键词】 外周血T淋巴细胞亚群；免疫球蛋白；手足口病；免疫功能；价值 　　DOI：10.14163/j.cnki.11-5547/r.2017.07.015 　　Study of combined diagnostic value of peripheral T lymphocyte subsets and immunoglobulin level on immunologic function of hand-foot-and-mouth disease children ZENG Hai-lian， LIU Guo-lian. Department of Clinical Laboratory， Maoming City People’s Hospital， Maoming 525000， China 　　【Abstract】 Objective To explore combined detection of peripheral T lymphocyte subsets and immunoglobulin level in diagnosis of immunologic function of hand-foot-and-mouth disease children. Methods There were 200 hand-foot-and-mouth disease children as hand-foot-and-mouth disease group， and 100 health examination children as health group. Detection were made on CD3+， CD4+， CD8+， CD4+/CD8+， immunoglobulin （Ig）A， IgM and IgG level in two groups. Results The health group had higher CD3+， CD4+ and CD8+ levle [（65.83±7.24）%， （41.32±4.74）% and （25.27±3.13）%] than hand-foot-and-mouth disease group [（52.72±4.83）%， （32.45±3.21）% and （20.13±2.35）%]， and their difference had statistical significance （P0.05）. The health group had higher IgA and IgG level [（1.16±0.25） and （9.21±1.63） g/L] than hand-foot-and-mouth disease group [（0.58±0.13） and （7.87±1.21） g/L]， and their difference had statistical significance （P0.05）. Conclusion Combined detection of peripheral T lymphocyte subsets and immunoglobulin level shows high diagnostic value in hand-foot-and-mouth disease children. 　　【Key words】 Peripheral T lymphocyte subsets； Immunoglobulin； Hand-foot-and-mouth disease； Immuno