复方醋酸环丙孕酮联合二甲双胍治疗多囊卵巢综合征合并胰岛素抵抗有效性研究.docVIP

复方醋酸环丙孕酮联合二甲双胍治疗多囊卵巢综合征合并胰岛素抵抗有效性研究 　　[摘要] 目的 探讨复方醋酸环丙孕酮联合二甲双胍治疗多囊卵巢综合征（PCOS）合并胰岛素抵抗的效果和可能机制。 方法 选取本院2013年1月～2014年1月的120例PCOS合并胰岛素抵抗患者作为研究对象，随机分为CPA组和联合组，各60例。CPA组给予复方醋酸环丙孕酮治疗，联合组给予复方醋酸环丙孕酮联合二甲双胍治疗，比较两组的效果。 结果 CPA组的有效率为93.3%（56/60），联合组的有效率为98.3%（59/60），两组比较差异无统计学意义（P0.05）。联合组治疗后的LH、FSH、T水平显著低于CPA组治疗后，SHBG水平显著高于CPA组治疗后，差异有统计学意义（P0.05）。联合组治疗后的空腹胰岛素水平显著低于CPA组治疗后，GIR水平显著高于CPA组治疗后，差异有统计学意义（P0.05）。联合组治疗后的HDL-C水平显著高于CPA组治疗后，LDL-C水平显著低于CPA组治疗后，差异有统计学意义（P0.05）。 结论 复方醋酸环丙孕酮联合二甲双胍可以用来治疗PCOS合并胰岛素抵抗，具有临床可行性。 　　[关键词] 复方醋酸环丙孕酮；二甲双胍；胰岛素抵抗 　　[中图分类号] R711.75 [文献标识码] A [文章编号] 1674-4721（2015）06（a）-0138-04 　　Validity study of cyproterone acetate combined with metformin in the treatment of polycystic ovary syndrome with insulin resistance 　　YUAN Yan-fang1 LI Xiao-yue2▲ 　　1.Department of Gynaecology and Obstetrics，Maternal and Child Health Care Hospital of Dongguan City in Guangdong Province，Dongguan 523100，China；2.Department of Critical Care Medicine，Tangxia Hospital of Dongguan City in Guangdong Province，Dongguan 523710，China 　　[Abstract] Objective To explore the effectiveness and mechanism of cyproterone acetate combined with metformin in the treatment of polycystic ovary syndrome （PCOS） with insulin resistance. Methods 120 cases of PCOS with insulin resistance from January 2013 to January 2014 in our hospital were selected and randomly divided into the CPA group and the combination group，60 cases in each group.The effect of two groups was compared. Results The effective rate of the CPA group was 93.3%（56/60），the effective rate of the combination group was 98.3%（59/60），there was no significant difference （P0.05）.The level of LH，FSH，T after treatment in combination group was lower than that in CPA group after treatment，the level of SHBG after treatment in combination group was higher than that in CPA group after treatment，with significant difference（P 　　[Key words] Cyproterone acetate；Metformin；Insulin resistance 　　多囊卵巢综合征（polycystic ovary syndrome，PCOS）临床表现为闭经、肥胖、多毛和不孕，是临床常见的