大株红景天注射液对原发性高血压患者血清高敏C―反应蛋白动脉粥样硬化程度影响.docVIP

大株红景天注射液对原发性高血压患者血清高敏C―反应蛋白动脉粥样硬化程度影响 　　【摘要】目的 探讨大株红景天注射液对原发性高血压患者血清高敏C-反应蛋白（hs-CRP）、颈动脉粥样硬化程度的影响和意义。方法 选取我院2012年4月～2014年10月收治的原发性高血压患者134例作为研究对象，随机分为红景天组66例和对照组68例。两组均给予常规降压治疗，红景天组在此基础上给予大株红景天注射液10 ml/d，连续2周。观察治疗前后血清hs-CRP、颈动脉内膜中层厚度（IMT）水平的变化。结果 红景天组治疗后IMT、hs-CRP显著下降，与治疗前比较，差异有统计学意义（P0.05）。治疗2周后，红景天组与对照组血清hs-CRP比较，差异有统计学意义（P0.05），但有降低的趋势。结论 大株红景天注射液能使原发性高血压患者的血清hs-CRP更快恢复至正常水平，明显减低IMT，其机制可能与阻断动脉粥样硬化炎症反应过程有关。 　　【关键词】原发性高血压；动脉粥样硬化；高敏C-反应蛋白；颈动脉内膜中层厚度 　　【中图分类号】R544.1 【文献标识码】B 【文章编号】ISSN.2095-6681.2015.10.0.03 　　【Abstract】Objective To explore the influence and significance of serum hs-CRP and AS of patients with Primary Hypertension with Sofren injection.Methods 134 patients were randomly divided into two groups，66 cases as roseroot group and 68 cases as control group；The two groups were given conventional therapy，and the treatment group was given Sofren Injection 10 ml intravenous drip based on routine treatment，1 time a day. The two groups were treated for 2 weeks. then the content of serum hs-CRP and IMT of two groups were analyzed.Results In the roseroot group after treatmen IMT and serum hs-CRP decreased（P0.05）；in the control group after treatmen serum hs-CRP decreased（P0.05），but IMT showed no significant difference.The content of serum hs-CRP of roseroot group was lower than those of control group after 2 weeks of treatment（P0.05）.The content of IMT of roseroot group and control group showed no significant difference after 2 weeks of treatment，but there is a tendency of decreasing. Conclusion Sofren Injection can cause the Primary Hypertension patients with serum hs-CRP quickly returned to normal level.The mechanism may be related to the blocking inflammatory reaction of atherosclerosis. 　　【Key words】Primary hypertension；Atherosclerosis；hs-CRP；IMT 　　原发性高血压（Primary hypertension PH）是以体循环动脉压升高为主要临床表现，目前我国18岁以上成人高血压发病率已达18.8%。长期的高血压导致动脉粥样硬化（Atherosclerosis AS），是高血压并发症形成的病理基础。Ross[1]等发现炎症参与了AS的病理过程，炎症的进展同样加速了AS的进展，并提出AS是一种慢性炎症性疾病。研究表明[2]，hs-CRP是低水平炎症的敏感标志物，是动脉粥样