奥曲肽联合泮托拉唑治疗胃十二指肠溃疡出血临床应用价值.docVIP

奥曲肽联合泮托拉唑治疗胃十二指肠溃疡出血临床应用价值 　　[摘要] 目的 探讨奥曲肽联合泮托拉唑治疗胃、十二指肠溃疡出血的临床应用价值。 方法 选取本院收治的68例胃、十二指肠溃疡患者，随机分为实验组和对照组，对照组给予泮托拉唑治疗，实验组给予奥曲肽联合泮托拉唑治疗，比较两组患者的止血情况、不良反应情况以及疗效。 结果 实验组治疗后24 h的止血成功率高于对照组（P0.05），实验组患者的腹痛、腹泻和脓血便等不良反应发生率低于对照组，两组差异有统计学意义（P0.05），实验组的治疗总有效率高于对照组，两组差异有统计学意义（P0.05）。 结论 奥曲肽联合泮托拉唑治疗胃、十二指肠溃疡出血的止血效果好，不良反应少，疗效确切。 　　[关键词] 奥曲肽；泮托拉唑；胃、十二指肠溃疡出血；应用价值 　　[中图分类号] R573.1 [文献标识码] A [文章编号] 1674-4721（2014）04（b）-0074-03 　　[Abstract] Objective To explore the clinical application value of pantoprazole combined with octreotide treatment of stomach and duodenum ulcer bleeding. Methods 68 patients with stomach and duodenum ulcer bleeding in our hospital were randomly divided into experimental group and control group，the control group patients were given pantoprazole treatment，the experimental group patients were given not only pantoprazole but also octreotide treatment，the curative effect，adverse reaction and the bleeding situation in two groups were compared. Results The hemostatic rate after the treatment of 24 h in experimental group was higher than that of the control group （P0.05），the incidence of adverse reactions such as abdominal，diarrhea and purulent blood stool was less in the experimental group than that of the control group respectively，the difference was statistically significant （P0.05），the efficiency of experimental group after treatment was higher than that of the control group，the difference was statistically significant （P0.05）. Conclusion The pantoprazole combined with octreotide treatment of stomach and duodenum ulcer bleeding has good effective，less adverse reaction and curative effect. 　　[Key words] Octreotide；Pantoprazole；Stomach and duodenum ulcer bleeding；Application value 　　消化性溃疡主要发生于胃和十二指肠，是一种较为常见的消化系统疾病，有研究发现[1]，20%～25%的消化性溃疡患者并发出血，由于发病较急且不易诊断，患者若出血过多则容易导致休克甚至死亡[2]。临床上患者常表现为呕血和黑便，出血速度越快、出血量越多表明患者的病情越严重。消化性溃疡出血患者的首要治疗任务是止血。泮托拉唑作为新一代质子泵抑制剂，效果较为显著，能有效减少胃酸分泌，治疗胃溃疡和消化性溃疡的效果较好[3]；奥曲肽作为一种人工合成的内源性生长抑素类药物，可在一定程度上抑制胃肠蠕动并降低胃肠血流量，同时抑制胃酸分泌[4]。本研究选取本院收治的68例胃、十二指肠