奥施康定与多瑞吉治疗癌痛毒副作用比较观察.docVIP

奥施康定与多瑞吉治疗癌痛毒副作用比较观察 　　【摘要】 目的：研究对比奥施康定与多瑞吉在治疗癌痛中的毒副作用。方法：选择2011年11月-2013年11月笔者所在医院收治的80例癌痛患者进行研究，分为试验组和对照组。试验组40例患者采用多瑞吉（芬太尼透皮贴剂）治疗，对照组40例患者采用奥施康定（盐酸羟考酮控释片）治疗。经不同治疗后，对两组患者毒副作用进行比较分析。结果：对于一些症状明显的患者，经过适当处理后能够继续用药。试验组消化系统毒副作用便秘与恶心呕吐的发生率分别为20.0%、10.0%，低于对照组（22.5%、20.0%），但两组比较差异均无统计学意义（P0.05）。试验组神经系统毒副作用头晕、嗜睡和精神异常的发生率分别为7.5%、5.0%和5.0%，低于对照组（12.5%、10.0%、10.0%），但两组比较差异均无统计学意义（P0.05）。结论：奥施康定与多瑞吉治疗癌痛的毒副作用均不严重，易于处理，较为安全。 　　【关键词】 奥施康定； 多瑞吉； 癌症疼痛； 毒副作用 　　中图分类号 R979.1 文献标识码 B 文章编号 1674-6805（2014）17-0038-02 　　【Abstract】 Objective：To study and compare the toxic side effect of Oxycontin and Duragesic in the treatment of cancer pain.Method：80 cases of cancer pain patients who were being treated at author’s hospital from November 2011 to November 2013 were chosed，were divided into the experimental group（40 cases） and the control group（40 cases）.The experimental group was treated with Duragesic（Fentanyl Transdermal），the control group was treated with Oxycontin （Oxycodone Hydrochloride Controlled-release Tablets）.After different treatment，the toxic side effect of two groups were compared and analyzed.Result：For some markedly symptomatic patients，after appropriate treatment，they could continue to medicine.In the experimental group，the incidence of constipation was 20.0%，nausea and vomiting were 10.0%，were lower than the control group（22.5%，20.0%），but comparing the two groups had no statistical significance（P0.05）.The incidence of dizziness，sleepiness，mental disorder in neurological side of the experimental group were 7.5%，5.0% and 5.0%，were lower than the control group（12.5%， 10.0% and 10.0%），but no statistical difference was found between two groups（P0.05）.Conclusion：The toxic side effect about using Oxycontin and Duragesic to treat cancer pain are not serious，are easy to handle，and are relative safer. 　　【Key words】 Oxycontin； Duragesic； Cancer pain； Toxic side effect 　　First-author’s address：Chenghai District People’s Hospital of Shantou City，Shantou 515800，China 　　癌痛是中晚期癌症患者