妊娠期糖尿病与血清炎症因子水平相关性分析.docVIP

妊娠期糖尿病与血清炎症因子水平相关性分析 　　[摘要] 目的 探讨妊娠期糖尿病（GDM）患者血清炎症因子水平与血糖水平的相关性。 方法 选取2014年7月～2015年7月新疆医科大学第二附属医院就诊并定期进行产前检查的中晚期孕妇100例作为研究对象，通过孕妇糖耐量的结果将其分为GDM组66例和正常糖耐量（NGT）组34例。分别检测两组对象血清中超敏C反应蛋白（hs-CRP）、血清淀粉样蛋白A（SAA）、白细胞介素-1β（IL-1β）和糖化血红蛋白（HbA1c）的水平，根据GDM组患者孕28周时HbA1c水平的不同，将患者分为两组：血糖控制较差组（HbA1c≥7.0%）和血糖控制较好组（HbA1c7.0%），比较两组的血清炎症因子水平及GDM组中不同血糖水平与其血清炎症因子水平的相关性。 结果 GDM组血清hs-CRP、SAA、IL-1β水平明显高于NGT组，差异有统计学意义（P 0.05）；GDM组中血糖控制较差组患者的hs-CRP、SAA、IL-1β水平显著高于血糖控制较好组，差异均有统计学意义（P 0.05）。 结论 GDM患者的血清hs-CRP、SAA、IL-1β水平显著增高，并且是影响血糖水平变化的重要因素，提示hs-CRP、SAA、IL-1β可能通过多种机制参与并加重GDM。 　　[关键词] 妊娠期糖尿病；超敏C反应蛋白；血清淀粉样蛋白A；白细胞介素-1β 　　[中图分类号] R714.256 [文献标识码] A [文章编号] 1673-7210（2016）05（c）-0116-04 　　[Abstract] Objective To investigate the correlation between the level of serum inflammatory factors and gestational diabetes mellitus （GDM）. Methods From July 2014 to July 2015， 100 middle and late pregnant women given regular prenatal care in the Second Affiliated Hospital of Xinjiang Medical University were divided into GDM group （66 patients） and normal glucose tolerance （NGT） group （34 patients） by the results of the glucose tolerance. The levels of high-sensitivity C-reactive protein （hs-CRP）， serum amyloid A （SAA）， interleukin -1β （IL-1β） and glycated hemoglobin （HbA1c） of two groups were detected. The pregnant women of the GDM group were divided into two groups according to level of HbA1c at 28 weeks： 66 cases of poor glycemic control group （HbA1c≥7.0%） and 34 cases of better blood glucose control group （HbA1c7.0%）. The levels of inflammatory cytokines were compared between two groups， then the correlation between levels of blood glucose and inflammatory cytokines of GDM group was analyzed. Results Levels of hs-CRP， SAA and IL-1β in the GDM group were higher than those of the NGT group， the differences were statistically significant （P 0.05）； the levels of hs-CRP， SAA and IL-1β of patients in the poor glycemic control group were higher than those of the better blood glucose control group， the differences