宫颈环形电切术对宫颈上皮内瘤变患者阴道病原体感染率影响观察.docVIP

宫颈环形电切术对宫颈上皮内瘤变患者阴道病原体感染率影响观察 　　【摘要】目的：探讨宫颈LEEP术对宫颈上皮内瘤变（CIN）患者的阴道病原体感染的疗效，研究的病原体主要包括高危型人乳头瘤病毒（ HPV）、沙眼衣原体（Ct） 及常见的阴道感染菌群如链球菌、大肠杆菌。方法：选取于2010年6月至2013年6月间于我院接受治疗的宫颈上皮内瘤变（CINⅡ～CINⅢ）患者166例作为此次研究的样本，所有样本个体均有生育史。所选样本个体均在月经干净后3～7 d行宫颈LEEP术治疗，且术前均进行相关病原菌的检测，手术后1个月进行复查，并在术后进行定期随访。随访时对相关病原菌进行检测，比较手术前后患者病原体感染情况。结果：166例患者中所有患者的随访资料均得到及时反馈，该166例患者宫颈LEEP术前后人乳头瘤病毒（HPV）的感染率有明显差异（P005）；常见的阴道感染菌群如链球菌、大肠杆菌的感染率在手术前后无差异，不具有统计学意义（P005）。结论：宫颈LEEP术对宫颈上皮内瘤变患者人乳头瘤病毒（HPV）的感染具有较好的治疗效果，手术前后HPV感染率明显下降；对于沙眼衣原体的感染效果较差，而对于常见的阴道感染菌群不具有治疗效果。 　　【关键词】宫颈环形电切术；宫颈上皮内瘤变；人乳头瘤病毒；沙眼衣原体；感染 　　【Abstract】Objective： To investigate the efficacy of the cervical LEEP procedure on cervical intraepithelial neoclassic （CIN） patients with vaginal pathogens infection. The pathogens included high-risk human papillomavirus （HPV）， Chlamydia trachoma （CT） and common vaginal bacteria， such as streptococcus and E. coli. Methods： 166 cases of cervical intraepithelial neoclassic （CINⅡ ～ CINⅢ） in our hospital from June 2010 to June 2013 were selected and all had reproductive history. The patients received cervical LEEP treatment after 3 ～ 7 d menstrual clean and related pathogens were detected before the treatment. Reexamination was conducted a month after the surgery. Regular follow-up was done after the treatment to detect the pathogens. Infection status of the patients before and after the surgery was compared. Results： All the 166 patients had effective follow-up data. Before and after the cervical LEEP surgery， the papillomavirus （HPV） infection rates were significantly different （P 005）； common vaginal infection bacteria such as streptococcus， E. coli had no statistically significant difference before and after surgery （P 005）. Conclusion： Cervical LEEP surgery for patients with cervical intraepithelial neoclassic （CIN） papillomavirus （HPV） infection has a better therapeutic effect. The HPV infection rate is significantly decreased after treatment； it has poor effect on Chlamydia trachoma （CT） infection and no therapeut