TPH2基因甲基化及相关危险因素与精神病自杀行为的关联-流行病学与卫生统计学专业论文.docxVIP

汕头大学硕士学位论文 汕头大学硕士学位论文 PAGE PAGE IV of suicidal behavior in mental disorder patients.Depression and schizophrenia were too. Lower frequency methylation of TPH2 gene promoter may be a kind of defense mechanism to mental disorder suicide patients. Keyword mental disorders; suicidal behavior; TPH2 gene; methylation 缩 略 语 PSY Psychoses SCB Suicidal Behavior DEP Depression SCH Schizophrenia MAN Manic HPA axis Hypothalamic-Pituitary-Adrenal Cortex Axis CSF Cerebrospinal Fluid 5-HT Serotonin TPH Tryptophan hydroxylase 5-HTT Serotonin Transporter VMAT2 Vesicular Monamine Transporter-2 5-HTR Serotonin Receptor MAO Monoamine Oxidase 5-HIAA 5-hydroxyindole Acetic Acid cAMP Cyclicadenylicacid mRNA Messenger Ribonucleic Acid CaMKII Calcium/calmodulin-dependent Protein Kinase II GSK-3p Glycogen Synthase Kinase-3p LOH Loss of Heterozygosity SAM S-adenosylmethionine TF Transcription Factor MDBP Methylated DNA binding Protein SNP Single Nucleotide Polymorphism MeCPs MethylGpG binding Proteins CCMD Chinese Classification of Mental Disorders ICD International Classification of Diseases DSM-Ⅳ Diagnostic and Manual of Mental Disorder 4th DIGS Diagnostic Investigation Genet Scale HRSD Hamilton Depression Rating Scale for Depression HAMA Hamilton Anxiety Scale BRMS Bech－Rafaelsen Mania Rating Scale BPRS Brief Psychiatric Scale MSP Methylation Specific PCR PCR Polymerase Chain Reaction 目 录 中文摘要·································································(Ⅰ) 英文摘要·································································(Ⅱ) 缩略语···································································(Ⅳ) 目录 ····································································(Ⅵ) 第 1 章 前 言······························································（1） 第 2 章 材料与方法·························································（6） 2.1 研究对象····························································（6） 2.2 研究方法····························································（6） 2.2.1 相关临床资料的