TSA上调食管癌EC9706柯萨奇腺病毒受体表达的研究-病理与病理生理学专业论文.docxVIP

啊!j倒jlw 原创性声明 本人郑童声明 z 所呈交的学位论文，是本人在导师的指导下，独立进行研 究所取得的成果。除文中已经注明引用的内容外，本论文不包含任何其他个人 或集体巳经发表或撰写过的科研成果。对本文的研究作出重要贡献的个人和集 体，均已在文中以明确方式标明。本声明的法律责任由本人承担。 学位论文作者: 日期z 年 月 日 学位论文使用授权声明 本人在导师指导下完成的论文及相关的职务作品，知识产权归属郑州大学。 根据郑州大学有关保留、使用学位论文的规定，同意学校保留或向国家有关部 门或机构送交论文的复印件和电子版，允许论文被查阅和借阅:本人授权郑州 大学可以将本学位论文的全部或部分编入有关数据库进行检索，可以来用影印、 缩印或者其他复制手段保存论文和汇编本学位论文。本人离校眉发表、使用学 位论文或与该学位论文直接相关的学术论文戒成果时，第一署名单位仍然为郑 州大学。保密论文在解密后应遵守此规定。 学位论文作者: 日期: 年月 H ， IV IV Abstract TSA increases coxsackie adenovirus receptor expression in the esophageal cancer EC9706 Postgraduate Xia Liu Tutor Prof.Ziming Dong School of Basic M创iω1 Scienc俑， Zhen部hou Universit弘 Zhengzhou 450052 China Abstract Background Adenovirusωanonωlytic virus or gene th町apy vectors has been widely used in cancer treatment，now 由e life cyc1e of adenovirus level of awareness to transform， so 曲时 specific lysis of tumor cells without an effe悦。n normal cells，by gen创cally engine配ed adenovirus，with a c严。lytic r叩lication cycle characteristics and specificity of targeting tumor cells and tumor ce1l 1ysis function. Oncol泸:ic viruses for cancer treatment 岛r nearly 60 years of h story，has been a lot of research on 伽e … transformation of the virus，routes of administration exploration，obs即vation， mechanisms and risk a wide range of areas discussion， so that pωpleund缸standing of tumor virus has developed greatl弘Oncolytic virus is expected to become an important weapon for 位eatment of cancer. The coxsackie adenovirus receptor CAR 邸 a virus，adeno virus ent町s cells，a major receptor in different cell surface expression level of a direct impact on the virus into the cell and after a series ofbiological effects produced b弘 not only in normal cell su由ce expression of different，but also 叽le expression of different tumor cells are very different. These results suggest that different types of 阳mor cellsurface receptor abundance of research-based ， predictable sensitivity of cells to adenovirus and treatment e的ct，which is predicted