沙美特罗丙酸氟替卡松联合盐酸氨溴索对慢性阻塞性肺疾病患者肺功能和血气指标影响.docVIP

沙美特罗丙酸氟替卡松联合盐酸氨溴索对慢性阻塞性肺疾病患者肺功能和血气指标影响 　　[摘要] 目的 探讨沙美特罗/丙酸氟替卡松联合盐酸氨溴索对慢性阻塞性肺疾病（COPD）患者肺功能和血气指标的影响。 方法 选取2011年1月～2014年6月在本院就诊的确诊为COPD的患者200例，根据治疗方法不同分为观察组和对照组，对照组给予沙美特罗/丙酸氟替卡松（沙美特罗50 μg/丙酸氟替卡松250 μg）每次1吸，2次/d。观察组在对照组治疗的基础上给予盐酸氨溴索30 mg，口服，2次/d。观察两组肺功能和血气指标的变化。 结果 治疗前两组患者的FEV1，FVC、FEV1/FVC，FEV1%比较，差异无统计学意义（P0.05）；治疗后3个月观察组的FEV1、FVC、FEV1/FVC、FEV1%高于对照组，差异有统计学意义（P0.05）；治疗后3个月观察组的PaO2高于对照组，PaCO2低于对照组，差异有统计学意义（P0.05）。治疗后3个月，观察组急性发作0次者90例（90%），对照组急性发作0次者73例（73%），两组急性发作0次者比率差异有统计学意义（P0.05）。 结论 沙美特罗/丙酸氟替卡松联合盐酸氨溴索治疗COPD效果明显，可有效改善患者肺功能及血气指标，提高患者的生活质量。 　　[关键词] 沙美特罗/丙酸氟替卡松；盐酸氨溴索；慢性阻塞性肺疾病；肺功能；血气分析；影响 　　[中图分类号] R974 [文献标识码] A [文章编号] 1674-4721（2015）01（b）-0088-03 　　Effect of salmeterol/fluticasone propionate combined with ambroxol on pulmonary function and blood gas in patients with chronic obstructive pulmonary disease 　　JIAN Ya-mei ZHANG Shao-xing FENG Yong-lin 　　Department of Respiration，Xingang Central Hospital of Xinyu City in Jiangxi Province，Xinyu 338001，China 　　[Abstract] Objective To investigate the effect of salmeterol/fluticasone propionate combined with ambroxol on pulmonary function and blood gas in patients with chronic obstructive pulmonary disease （COPD）. Methods 200 cases of patients with COPD in our hospital from January 2011 to June 2014 were selected，according to the different treatment methods，they were divided into observation group and control group，the control group were treated with salmeterol/fluticasone propionate （salmeterol 50 μg/ fluticasone propionate 250 μg） every time 1 suction，2 times a day；ambroxol was added to the observation group on the basis of control group，30 mg orally 2 times a day.The pulmonary function and blood gas index of the two groups was observed. Results Before treatment，the FEV1，FVC，FEV1/FVC，FEV1% of two groups had no significant （P0.05）；after 3 months treatment，the FEV1，FVC，FEV1/FVC，FEV1% of observation group was higher than that of control group，the difference was significant （P0.05）；after 3 months treatment，PaO2 of the ob