泛昔洛韦联合半导体激光治疗带状疱疹临床研究.docVIP

泛昔洛韦联合半导体激光治疗带状疱疹临床研究 　　 【摘要】目的:观察泛昔洛韦联合半导体激光治疗带状疱疹的疗效。方法：将94例患者随机分为试验组和对照组，两组均口服泛昔洛韦250 mg，每日3次，共7天，试验组加用半导体激光照射神经根和疼痛最明显区域，每日照射2次，每次10分钟，共7天。结果：试验组痊愈率85.41％，对照组痊愈率65.21%，痊愈率差异有显著性（P0．01）。两组总有效率相当，无统计学意义，试验组在水疱停止出现时间、水疱干涸时间、疼痛缓解时间、完全结痂时间均优于对照组，差异有显著性（P0.01）。试验组后遗神经痛的发生率低，差异有显著性（P0.05）。结论: 泛昔洛韦联合半导体激光治疗带状疱疹疗效好，安全，降低了后遗神经痛的发生率。 　　【关键词】联合治疗；泛昔洛韦；半导体激光；带状疱疹 　　文章编号：1009-5519（2007）11-1593-02 中图分类号：R75 文献标识码：A 　　 　　Clinical research of combinedfamciclovir and diode laser inthe treatment of herpes zoster 　　HU Ze-fang，HU Li，LI Hui 　　（Department of Dermatology，The First Affiliated Hospital， Chongqing Medical University，Chongqing 400016，China） 　　【Abstract】Objective：To observe the therapeutic effect of combined famciclovir and diode laser inherpes zoster. Methods:94 patients with herpes zoster were randomly divided into two groups：trial group and control group. The two groups were both given oral famciclovir tablets 0.25 g three times per day; and the trial group were additionally given ten-minute diode laser treatment twice per day.The therapeutic course was 7 days. Results:At the end of the treatment，the complete rehabilitation rate in the trial group was superior to that in the control group (85.41％ VS 65.21%，P0.01)， without significant difference in curative effect. Furthermore， the time of blister stopping emergence and drying up， the time of pain releasing and complete incrustation in trial group were all shorter than those in control group(P0.01). Meanwhile，The incidence of postherapeutic neuralgia was significantly lower in trial group(P0.05). Conclusion: Combined famciclovirand diode laser was an effective and safe treatment for herpes zoster，with lower incidence of postherapeutic neuralgia. 　　【Key words】Combination treatment；Famciclovir；Diode laser treatment；Herpes zoster 　　 　　 　　我们于2005年1月~2006年12月用泛昔洛韦联合半导体激光治疗带状疱疹，取得了很好的治疗效果，现总结如下。 　　 　　1 资料和方法 　　 　　1.1 一般资料：随机选择门诊及住院患者94例，年龄l8岁以上，诊断均符合《临床皮肤病学》[1]第三版带状疱疹的诊断要点。病程1周以内(且未接受过抗病毒治疗)。对有严重心肝肾疾病，妊娠或哺乳期妇女，