注射用复方甘草酸苷联合阿昔洛韦治疗带状疱疹及后遗神经痛临床疗效观察.docVIP

注射用复方甘草酸苷联合阿昔洛韦治疗带状疱疹及后遗神经痛临床疗效观察 　　[摘要] 目的 观察注射用复方甘草酸苷联合阿昔洛韦治疗带状疱疹及后遗神经痛的临床疗效。 方法 选取2013年1月～2014年1月我院住院治疗的带状疱疹患者60例作为研究对象，随机分为观察组（n=30，采用注射用复方甘草酸苷联合阿昔洛韦治疗）和对照组（n=30，采用阿昔洛韦治疗），比较两组治疗后的总有效率、两组的止疱时间、结痂时间、止痛时间。 结果 观察组治疗后的总有效率达90%，显著高于对照组治疗后的总有效率（73.3%），组间比较，差异具有统计学意义（x2=6.387，P0.05）。观察组的止疱时间、结痂时间、止痛时间均分别为（2.56±1.07）d、（3.23±0.85）d、（5.61±1.07）d， 对照组的止疱时间、结痂时间、止痛时间均分别为（4.32±1.12）d、（5.96±1.03）d、（8.93±1.02）d、 两组比较具有统计学差异（P0.05）。 结论 注射用复方甘草酸苷联合阿昔洛韦治疗带状疱疹及后遗神经痛具有较好的疗效，值得推广。 　　[关键词] 带状疱疹；后遗神经痛；复方甘草酸苷；阿昔洛韦 　　[中图分类号] R752.12 [文献标识码] B [文章编号] 2095-0616（2015）15-109-03 　　[Abstract] Objective To observe the clinical efficacy of acyclovir combined with Glycyrrhizin in treatment of herpes zoster and postherpetic neuralgia. Methods A total of 60 inpatients with herpes zoster and postherpetic neuralgia from January 2013 to January 2014 in our hospital were selected as the research object， randomly divided into observation group （n=30， Glycyrrhizin Combined with acyclovir） and control group （n=30，Glycyrrhizin），the efficiency rate， Blister stop time，the scab time， pain time were compared between two groups after treatment. Results The total effective rate of observation group was 90%， was significantly higher than that of the control group （73.3%） ，the difference was significant between two groups（x2=6.387， P0.05）. The check blister time， scabby time， duration of analgesia in observation group were shorter than the control group，the difference was significant between two groups （P0.05）. Conclusion Acyclovir combined with Glycyrrhizin in treatment of herpes zoster and postherpetic neuralgia have exact effect，and can significantly improve the patients clinical symptoms， reduce the pain of patients，and it is worth of clinical promotion and application. 　　[Key words] Herpes zoster； Neuralgia； Compound glycyrrhizin； Acyclovir 　　带状疱疹（herpeszoste）是皮肤科的常见病、多发病，是由水痘-带状疱疹病毒引起的病毒感染性皮肤病，多伴有明显的神经痛，且皮疹消退后常会遗留神经痛，严重影响患者的生活质量[1]。抗病毒、营养神经?p减少疼痛、预防继发感染、缩短病程、预防后遗神经痛是带状疱疹治疗的关键[2]。糖皮质激素为常用治疗方法，可抑制本病的炎症